2. Immunology/Inflammation
  3. AP-1
  4. SR 11302

SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE).

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CAS 番号 : 160162-42-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 198 在庫あり
Solution
10 mM * 1 mL in DMSO USD 198 在庫あり
Solid
1 mg $110 在庫あり
5 mg $180 在庫あり
10 mg $280 在庫あり
25 mg $480 在庫あり
50 mg $790 在庫あり
100 mg $1260 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 24 publication(s) in Google Scholar

Other Forms of SR 11302:

SR 11302 関連抗体

Top Publications Citing Use of Products

    SR 11302 purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8098):1013-1021.  [Abstract]

    Cell viability of MCF7 and T47D cells treated with tamoxifen and increased concentrations of AP-1 inhibitor SR11302 (1-20 μM), alone or in combination. Data are from three biological replicates and are presented as mean ± SD. P-values represents Kruskal-Wallis followed by Dunn post-hoc correction.

    SR 11302 purchased from MedChemExpress. Usage Cited in: Environ Health Perspect. 2025 Apr 9.  [Abstract]

    WB of ATF3 and JunB in AML12 cells after SR11302 (2 μM, 24 h) treatment.

    SR 11302 purchased from MedChemExpress. Usage Cited in: Environ Health Perspect. 2025 Apr 9.  [Abstract]

    Nile Red staining of AML12 cells in the control, BPS (100 μM), and BPS+SR11302 (2 μM, 24 h) group.

    SR 11302 purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2025 Oct 10:2025:1240226.  [Abstract]

    Annexin V/7-AAD flow cytometry showing that si-FOS, SR11302 (5 μM, 24 h), or UA treatment reduced IL-1β-induced apoptosis compared with IL-1β + si-NC.

    SR 11302 purchased from MedChemExpress. Usage Cited in: Nature. 2025 Jan;637(8045):402-411.  [Abstract]

    Western blots (top) and signal intensity (bottom) of BLM in E12.5 fetal liver Lin– HSPCs cultured with or without FetuA and the bZIP inhibitor SR11302 (2 mM, 6 h).

    AP-1 アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE)[1].

    IC50 & Target

    AP-1[1]
    体外実験

    SR 11302 (SR11302) show strong anti-AP-1 activity with selective binding with RARα and RARγ, but not with RARβ and RXRα[1].
    SR 11302 (SR-11302; 1 μM) inhibits AP-1 transcription factor activity and decreases aldosterone levels by 61.9% in hypoxia-treated cells[2].
    SR 11302 (SR-11302; 2 μM; 48 hours) inhibits Helicobacter pylori (H. pylori)-induced cell proliferation in adenocarcinoma gastric (AGS) cells[3].
    SR 11302 (2 μM; 24 hours) inhibits H. pylori-induced expression of β-catenin and c-myc in AGS cells[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SR 11302 関連抗体
    体内実験

    SR 11302 (SR11302; low dose 0.5 mg/kg and high dose 1 mg/kg body weight; orally gavaged daily) treatment reduces the total vascular lesion number and lesion size in Vldlr-/- mice in a dose-dependent manner[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Vldlr-/- mice[4]
    Dosage: Low dose 0.5 mg/kg and high dose 1 mg/kg body weight
    Administration: Orally gavaged daily from P5 to P15
    Result: High-dose from P5 to P15 reduced the total vascular lesion number by 48% and decreased the lesion size by 40%, without detectable signs of toxicity in mice, including no change in body weight.
    分子量

    376.53

    分子式

    C26H32O2
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(O)/C=C(C)/C=C/C=C(C1=CC=C(C)C=C1)/C=C/C2=C(C)CCCC2(C)C
    輸送条件

    Shipping with dry ice.
    保管条件

    -80°C, protect from light
    溶剤 & 溶解度
    体外: 

    DMSO : 33.33 mg/mL (88.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6558 mL 13.2792 mL 26.5583 mL
    5 mM 0.5312 mL 2.6558 mL 5.3117 mL
    10 mM 0.2656 mL 1.3279 mL 2.6558 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: 99.44%

    COA (246 KB) HNMR (257 KB) RP-HPLC (257 KB) Elemental Analysis Report (104 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months (protect from light). When stored at -80°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.6558 mL 13.2792 mL 26.5583 mL 66.3958 mL
    5 mM 0.5312 mL 2.6558 mL 5.3117 mL 13.2792 mL
    10 mM 0.2656 mL 1.3279 mL 2.6558 mL 6.6396 mL
    15 mM 0.1771 mL 0.8853 mL 1.7706 mL 4.4264 mL
    20 mM 0.1328 mL 0.6640 mL 1.3279 mL 3.3198 mL
    25 mM 0.1062 mL 0.5312 mL 1.0623 mL 2.6558 mL
    30 mM 0.0885 mL 0.4426 mL 0.8853 mL 2.2132 mL
    40 mM 0.0664 mL 0.3320 mL 0.6640 mL 1.6599 mL
    50 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3279 mL
    60 mM 0.0443 mL 0.2213 mL 0.4426 mL 1.1066 mL
    80 mM 0.0332 mL 0.1660 mL 0.3320 mL 0.8299 mL
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    SR 11302 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SR 11302160162-42-5SR11302SR-11302AP-1Activator Protein 1activatorprotein-1retinoicacidresponseelementRARELungCancerretinoidInhibitorinhibitorinhibit

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    製品名:
    SR 11302
    製品番号:
    HY-15870
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