2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Streptolysin O

Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state.

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Streptolysin O

Streptolysin O 화학구조

CAS No. : 98072-47-0

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Based on 2 publication(s) in Google Scholar

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Streptolysin O Related Antibodies

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제품 설명

Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state[1][2][3][4].

In Vitro

Streptolysin O is a labile toxin, and, with time, activity is irreversibly lost. The rate of activity loss is slowed by incubation with 0.1 M 2-mercaptoethanol or 0.01 M ethylenediaminetetraacetic acid (EDTA)[2].
Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection[3].

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Streptolysin O Related Antibodies
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Streptolysin O]
Structure Classification
Initial Source

streptococci
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : 1 mg/mL (Need ultrasonic)

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순도&문서

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Keywords:

Streptolysin O98072-47-0Endogenous Metaboliteoxygen-labilestreptococcalhemolysinprototypecholesterol-bindingbacterialexotoxinpermeabilizationvirulenceInhibitorinhibitorinhibit

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상품명:
Streptolysin O
Cat. No.:
HY-135416
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