2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Nuclear Hormone Receptor 4A/NR4A FXR
  4. Teduglutide

Teduglutide  (Synonyms: ALX-0600)

製品番号: HY-P1624 純度: 99.85%
COA 取扱説明書 Technical Support

Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

カスタムペプチド

Teduglutide

Teduglutide 構造式

CAS 番号 : 197922-42-2

容量 価格（税別） 在庫状況 数量
5 mg $220 在庫あり
10 mg $370 在庫あり
25 mg $740 在庫あり
50 mg $1200 在庫あり
100 mg $1900 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Teduglutide:

Teduglutide 関連抗体

Top Publications Citing Use of Products

Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Nur77/NR4A1 Nurr1/NR4A2

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis[1][2][3][4].
IC50 & Target

Nur77/NR4A1

 

体外実験

Teduglutide (2.5 μM, 36 h) can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 in human hepatic stellate cells[4].
Teduglutide can increase the proliferation of all intestinal segment epithelial cells and reduce cell apoptosis in the short intestine newborn piglet model[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Teduglutide 関連抗体

Real Time qPCR[4].

Cell Line: Human Hepatic Stellate Cells (HSC)
Concentration: 2.5 μM
Incubation Time: 36 h
Result: Increased transcription levels of NR4a1/Nur77.
体内実験

Teduglutide (0.1 mg/kg; twice daily; 2 weeks; s.c.) can alleviate intestinal dysfunction and nucleotide oligomeric domain 2 (Nod2) dysfunction induced intestinal failure in cecectomy mice[1].
Teduglutide (200 μg/kg; twice daily; 10 days; s.c.) has anti apoptotic and antioxidant activities in mice with lung injury[2].
Teduglutide (5 μg; once daily; 4 weeks; i.p.) can improve obesity related neuroinflammation, central stress, and cell apoptosis in mice fed a high-fat diet[3].
Teduglutide (0.05 mg/kg; once daily; 4 weeks; i.p.) improves liver inflammation and fibrosis in a Mdr2 mouse model of sclerosing cholangitis by activating NR4a1/nur77 in hepatic stellate cells and intestinal FXR signaling[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male mice undergoing 12-cm ileocecal and cecal resection (ICR)[1].
Dosage: 0.1 mg/kg
Administration: Subcutaneous injection (s.c.); twice daily; 2 weeks
Result: Resulted in a decrease in plasma aldosterone concentration, a decrease in fecal water content, and a decrease in fecal sodium loss.
Animal Model: A mouse model with lung injury induced by tumor necrosis factor-alpha (TNF-α) and actinomycin D (Act D)[2].
Dosage: 200 μg/kg
Administration: Subcutaneous injection (s.c.); twice daily; 10 days
Result: Attenuated structural damage, cell apoptosis, and oxidative stress by reducing lipid peroxidation in mice receiving TNF - α/AtD.
Animal Model: Mice fed a high-fat diet (HFD)[3].
Dosage: 5 μg
Administration: Intraperitoneal injection (i.p.); once daily; 4 weeks
Result: Reduced the expression of HFD induced pro-inflammatory mediators (NF kB, IL-8, TNF - α, IL-1 β, and IL-6), glial fibrillary acidic protein (GFAP), glial proliferation and neurodegeneration index, stress marker proteins (p-ERK, Hsp60, and i-NOS), and amyloid beta precursor protein (APP).
Animal Model: The Mdr2/Abcb4 mouse model of sclerosing cholangitis displaying hepatic inflammation and fibrosis[4].
Dosage: 0.05 mg/kg
Administration: Intraperitoneal injection (i.p.); once daily; 4 weeks
Result: Resulted in an increase in intrahepatic level of muricholic acids and serum Fgf15 level, as well as a decrease in mRNA levels of Cyp7a1 and FXR.
分子量

3752.13

分子式

C164H252N44O55S
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
Sequence Shortening

HGDGSFSDEMNTILDNLAARDFINWLIQTKITD
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (13.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 22.22 mg/mL (5.92 mM; ultrasonic and adjust pH to 2 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2665 mL 1.3326 mL 2.6652 mL
5 mM 0.0533 mL 0.2665 mL 0.5330 mL
10 mM 0.0267 mL 0.1333 mL 0.2665 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.85%

COA (260 KB) RP-HPLC (256 KB) MS (68 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.2665 mL 1.3326 mL 2.6652 mL 6.6629 mL
5 mM 0.0533 mL 0.2665 mL 0.5330 mL 1.3326 mL
DMSO 10 mM 0.0267 mL 0.1333 mL 0.2665 mL 0.6663 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Teduglutide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teduglutide197922-42-2ALX-0600ALX0600ALX 0600Nuclear Hormone Receptor 4A/NR4AFXRNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorNR1H4HSCintestinal functionlung injuryobesityInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Teduglutide
製品番号:
HY-P1624
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.