2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 6

Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases.

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Topoisomerase I inhibitor 6

Topoisomerase I inhibitor 6 Chemische Struktur

CAS. Nr. : 2393082-56-7

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Topoisomerase I inhibitor 6 Related Antibodies

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Beschreibung

Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 10 3
Compound: 3
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
HEK293 IC50
> 10 3
Compound: 3
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
HEK293 IC50
>10 3
Compound: 3
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
MCF7 IC50
2.5 3
Compound: 3
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
MCF7 IC50
2.5 3
Compound: 3
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
MCF7 IC50
2.5 3
Compound: 3
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay
[PMID: 32682183]
Molekulargewicht

411.46

Formel

C23H21N7O
CAS. Nr.
SMILES

NC1=CC=C(C=C1)C2=CC=C3N=CC(C4=NN=CO4)=C(C3=C2)NCCCN5C=CN=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Topoisomerase I inhibitor 6 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 62393082-56-7Topoisomerase I inhibitor6Topoisomerase I inhibitor-6TopoisomeraseTopoisomerase IDNA-Top1cytotoxiccancerInhibitorinhibitorinhibit

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