2. Anti-infection
  3. SARS-CoV Influenza Virus CHIKV
  4. Umifenovir

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.

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Umifenovir

Umifenovir 構造式

CAS 番号 : 131707-25-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 44 在庫あり
Solution
10 mM * 1 mL in DMSO USD 44 在庫あり
Solid
5 mg $42 在庫あり
10 mg $66 在庫あり
50 mg $238 在庫あり
100 mg $349 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 11 publication(s) in Google Scholar

Other Forms of Umifenovir:

Umifenovir 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3].

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
> 200 3
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
[PMID: 31753804]
HeLa EC50
>200 3
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
[PMID: 31753804]
HeLa EC50
> 200 3
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
[PMID: 31753804]
HeLa EC50
40 3
Compound: Arbidol
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
[PMID: 31753804]
HeLa EC50
40 3
Compound: Arbidol
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
[PMID: 31753804]
Huh-7 IC50
1 3
Compound: Arbidol
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
[PMID: 20638289]
HeLa EC50
40 3
Compound: Arbidol
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
[PMID: 31753804]
HeLa EC50
> 200 3
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
[PMID: 31753804]
MDCK CC50
46.44 3
Compound: arbidol
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
[PMID: 33631936]
Huh-7 IC50
1 3
Compound: Arbidol
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
[PMID: 20638289]
HeLa EC50
> 200 3
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
[PMID: 31753804]
MDCK IC50
32.5 3
Compound: Arbidol
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
[PMID: 32520560]
MDCK IC50
32.5 3
Compound: Arbidol
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
[PMID: 32520560]
Huh-7 IC50
1 3
Compound: Arbidol
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
[PMID: 20638289]
MDCK CC50
46.44 3
Compound: arbidol
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
[PMID: 33631936]
MRC5 CC50
376 3
Compound: 2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
Vero CC50
679.9 3
Compound: 2
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
MRC5 CC50
376 3
Compound: 2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
Vero CC50
161 3
Compound: Arbidol
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero CC50
161 3
Compound: Arbidol
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero CC50
31.79 3
Compound: 16
Cytotoxicity against african green monkey Vero cells incubated for 3 days
Cytotoxicity against african green monkey Vero cells incubated for 3 days
[PMID: 32539378]
Vero CC50
31.79 3
Compound: 16
Cytotoxicity against african green monkey Vero cells incubated for 3 days
Cytotoxicity against african green monkey Vero cells incubated for 3 days
[PMID: 32539378]
Vero EC50
35 3
Compound: Arbidol
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero EC50
35 3
Compound: Arbidol
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero 76 IC50
<20.9 3
Compound: Arbidol
Antiviral activity against CHIKV infected in Vero 76 cells assessed as reduction in cytopathic effect
Antiviral activity against CHIKV infected in Vero 76 cells assessed as reduction in cytopathic effect
[PMID: 38394369]
Vero CC50
679.9 3
Compound: 2
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
MDCK CC50
46.44 3
Compound: arbidol
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
[PMID: 33631936]
Vero C1008 CC50
>40 3
Compound: Arbidol
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
10.1101/2020.04.03.023846
Vero C1008 CC50
> 40 3
Compound: Arbidol
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
10.1101/2020.04.03.023846
Vero C1008 CC50
31.79 3
Compound: Arbidol
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
[PMID: 32771797]
Vero C1008 EC50
10.7 3
Compound: Arbidol
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
10.1101/2020.04.03.023846
MDCK IC50
32.5 3
Compound: Arbidol
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
[PMID: 32520560]
Vero C1008 CC50
31.79 3
Compound: Arbidol
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
[PMID: 32771797]
Vero C1008 EC50
10.7 3
Compound: Arbidol
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
10.1101/2020.04.03.023846
MRC5 CC50
376 3
Compound: 2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
Vero CC50
161 3
Compound: Arbidol
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero CC50
31.79 3
Compound: 16
Cytotoxicity against african green monkey Vero cells incubated for 3 days
Cytotoxicity against african green monkey Vero cells incubated for 3 days
[PMID: 32539378]
Vero CC50
679.9 3
Compound: 2
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
Vero EC50
35 3
Compound: Arbidol
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero 76 IC50
< 20.9 3
Compound: Arbidol
Antiviral activity against CHIKV infected in Vero 76 cells assessed as reduction in cytopathic effect
Antiviral activity against CHIKV infected in Vero 76 cells assessed as reduction in cytopathic effect
[PMID: 38394369]
Vero C1008 CC50
31.79 3
Compound: Arbidol
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
[PMID: 32771797]
Vero C1008 CC50
> 40 3
Compound: Arbidol
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
10.1101/2020.04.03.023846
Vero C1008 EC50
10.7 3
Compound: Arbidol
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
10.1101/2020.04.03.023846
体外実験

Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Umifenovir 関連抗体
体内実験

Umifenovir (25 and 45 mg/ml; p.o.) shows a survival benefit to mice suffering from influenza infection[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (6–8 weeks old), mice were intranasally (i.n.) inoculated with 2 times the 50% mouse lethal dose (MLD50) of A/ Guangdong/GIRD07/09 (H1N1) (104.5TCID50/mL) in a volume of 20mL[3].
Dosage: 1.25 mg/mL (25 mg/kg/day) and 2.25 mg/mL (45 mg/kg/day) in a total volume of 500mL at one day pre-infection and 3 days post-infection (dpi)
Administration: Oral administration
Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group.
分子量

477.41

分子式

C22H25BrN2O3S
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(CSC2=CC=CC=C2)N(C)C3=C1C(CN(C)C)=C(O)C(Br)=C3)OCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (104.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0946 mL 10.4732 mL 20.9464 mL
5 mM 0.4189 mL 2.0946 mL 4.1893 mL
10 mM 0.2095 mL 1.0473 mL 2.0946 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0946 mL 10.4732 mL 20.9464 mL 52.3659 mL
5 mM 0.4189 mL 2.0946 mL 4.1893 mL 10.4732 mL
10 mM 0.2095 mL 1.0473 mL 2.0946 mL 5.2366 mL
15 mM 0.1396 mL 0.6982 mL 1.3964 mL 3.4911 mL
20 mM 0.1047 mL 0.5237 mL 1.0473 mL 2.6183 mL
25 mM 0.0838 mL 0.4189 mL 0.8379 mL 2.0946 mL
30 mM 0.0698 mL 0.3491 mL 0.6982 mL 1.7455 mL
40 mM 0.0524 mL 0.2618 mL 0.5237 mL 1.3091 mL
50 mM 0.0419 mL 0.2095 mL 0.4189 mL 1.0473 mL
60 mM 0.0349 mL 0.1746 mL 0.3491 mL 0.8728 mL
80 mM 0.0262 mL 0.1309 mL 0.2618 mL 0.6546 mL
100 mM 0.0209 mL 0.1047 mL 0.2095 mL 0.5237 mL
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Umifenovir Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Umifenovir131707-25-0SARS-CoVInfluenza VirusCHIKVSARS coronavirusChikungunya virusoralinflammatoryenvelopedfusionvirusInhibitorinhibitorinhibit

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