2. Membrane Transporter/Ion Channel
  3. Monocarboxylate Transporter
  4. VB124

VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism.

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CAS No. : 2230186-18-0

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtenir un devis  
500 mg   Obtenir un devis  

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Based on 7 publication(s) in Google Scholar

VB124 Related Antibodies

Top Publications Citing Use of Products

    VB124 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Mar 18:102038.  [Abstract]

    Dose-response curves of the MCT4 inhibitor VB124 in HuH7 KO and Hepa1-6 KO cells.

    VB124 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Mar 18:102038.  [Abstract]

    Colony formation assays of HuH7 KO and Hepa1-6 KO cells treated with VB124 (10 μM).

    VB124 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Mar 18:102038.  [Abstract]

    KD of LDHA and treatment with the MCT1 inhibitor AR-C155858 and the MCT4 inhibitor VB124 (1, 10, 20 nM) significantly reduced the population of Foxp-3+ Treg cells.

    VB124 purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Mar 18:102038.  [Abstract]

    Tumorigenicity assay of Hepa1-6 KO cells in immunoproficient mice treated with anti-PD-1 antibody and VB124 (30 mg/kg, p.o.).

    VB124 purchased from MedChemExpress. Usage Cited in: Chin Med. 2025 Oct 23;20(1):180.  [Abstract]

    Representative immunoblot demonstrating β-MHC and ANP protein expression in H9C2 cells treated with VB124

    Voir tous les produits spécifiques à Isoform Monocarboxylate Transporter:

    Voir toutes les isoformes
    MCT1 MCT2 MCT4

    • Activité biologique

    • Pureté et documentation

    • Références

    • Avis client

    Description

    VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism[1].

    IC50 & Target

    MCT4

     

    In Vitro

    VB124 (10 μM) inhibits the cell proliferation of MDA-MB-231 cells, and the cell proliferation rate is less than 50%[1].
    VB124 is highly selective for MCT4 over MCT1, showing very little MCT1 inhibitory activity (lactate export IC50=24 μM) in MCT1-expressing BT20 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    VB124 Related Antibodies
    In Vivo

    VB124 (30 mg/kg; p.o.; daily for 28 days) attenuates isoproterenol-induced cardiac hypertrophy in mice[1].
    VB124 (30 mg/kg; twice per day for 180 days) has no effect on the body, heart, liver, or lung weight of mice, suggesting no overt toxicities[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 12 weeks old C57BL/6 mice[1]
    Dosage: 30 mg/kg
    Administration: Oral gavage; daily for 28 days (dissolved in 0.5% methylcellulose and 0.1% Tween-20)
    Result: Prevented cardiac hypertrophy in mice.
    Masse moléculaire

    426.89

    Formule

    C23H23ClN2O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(C)(OCC1=NN(C2=CC=CC=C2Cl)C(C3=CC=CC(OC4CC4)=C3)=C1)C(O)=O
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvant et solubilité
    In Vitro: 

    DMSO : 100 mg/mL (234.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3425 mL 11.7126 mL 23.4252 mL
    5 mM 0.4685 mL 2.3425 mL 4.6850 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Calculateur de molarité

    • Calculateur de dilution

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (5.86 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (5.86 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureté et documentation

    Purity: 99.86%

    SDS (251 KB)

    COA (254 KB) HNMR (269 KB) LCMS (106 KB)

    Instruction de manipulation (2659 KB)
    Références

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3425 mL 11.7126 mL 23.4252 mL 58.5631 mL
    5 mM 0.4685 mL 2.3425 mL 4.6850 mL 11.7126 mL
    10 mM 0.2343 mL 1.1713 mL 2.3425 mL 5.8563 mL
    15 mM 0.1562 mL 0.7808 mL 1.5617 mL 3.9042 mL
    20 mM 0.1171 mL 0.5856 mL 1.1713 mL 2.9282 mL
    25 mM 0.0937 mL 0.4685 mL 0.9370 mL 2.3425 mL
    30 mM 0.0781 mL 0.3904 mL 0.7808 mL 1.9521 mL
    40 mM 0.0586 mL 0.2928 mL 0.5856 mL 1.4641 mL
    50 mM 0.0469 mL 0.2343 mL 0.4685 mL 1.1713 mL
    60 mM 0.0390 mL 0.1952 mL 0.3904 mL 0.9761 mL
    80 mM 0.0293 mL 0.1464 mL 0.2928 mL 0.7320 mL
    100 mM 0.0234 mL 0.1171 mL 0.2343 mL 0.5856 mL
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    VB124 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    VB1242230186-18-0VB 124VB-124Monocarboxylate TransporterMDA-MB-231selectivecardiac hypertrophycelllactate effluxInhibitorinhibitorinhibit

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