2. Membrane Transporter/Ion Channel Others
  3. WNK Kinase Isotope-Labeled Compounds
  4. WNK-IN-11-d3

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis.

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WNK-IN-11-d<sub>3</sub>

WNK-IN-11-d3 構造式

CAS 番号 : 2123483-49-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 328 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO USD 328 お問い合わせ 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solid
1 mg $120 在庫あり
5 mg $320 在庫あり
10 mg $520 在庫あり
25 mg $1050 在庫あり
50 mg $1700 在庫あり
100 mg $2750 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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WNK-IN-11-d3 関連抗体

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製品説明

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

WNK[1]
体内実験

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague−Dawley rats[1]
Dosage: 1.5 mg/kg
Administration: P.o.
Result: Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.
Animal Model: FVB mice[1]
Dosage: 30 mg/kg
Administration: P.o.
Result: Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.
Animal Model: FVB mice[1]
Dosage: 0~100 mg/kg
Administration: P.o.
Result: Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.
分子量

465.41

分子式

C21H18D3Cl2N5OS
CAS 番号
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(CC1)CC2=CC=C(C=C2)Cl)C3=CC(C4=CSC(NC([2H])([2H])[2H])=N4)=NC=C3Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 100 mg/mL (214.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1486 mL 10.7432 mL 21.4864 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL
10 mM 0.2149 mL 1.0743 mL 2.1486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.84%

COA (246 KB) HNMR (134 KB) RP-HPLC (246 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1486 mL 10.7432 mL 21.4864 mL 53.7161 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL 10.7432 mL
10 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3716 mL
15 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5811 mL
20 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6858 mL
25 mM 0.0859 mL 0.4297 mL 0.8595 mL 2.1486 mL
30 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7905 mL
40 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
50 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
60 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8953 mL
80 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6715 mL
100 mM 0.0215 mL 0.1074 mL 0.2149 mL 0.5372 mL
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WNK-IN-11-d3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WNK-IN-11-d32123483-49-6WNK KinaseIsotope-Labeled CompoundsWith-no-lysine (WNK) kinaseorallyactiveselectivepotenteffectivecardiovascularhomeostasisInhibitorinhibitorinhibit

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製品名:
WNK-IN-11-d3
製品番号:
HY-112094S
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