2. Membrane Transporter/Ion Channel Others
  3. WNK Kinase Isotope-Labeled Compounds
  4. WNK-IN-11-d3

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis.

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WNK-IN-11-d<sub>3</sub>

WNK-IN-11-d3 화학구조

CAS No. : 2123483-49-6

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO 견적 받기 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of WNK-IN-11-d3:

WNK-IN-11-d3 Related Antibodies

Top Publications Citing Use of Products

View All WNK Kinase Isoform Specific Products:

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WNK2 WNK3 WNK4 WNK1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

WNK[1]
In Vivo

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability[1].
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague−Dawley rats[1]
Dosage: 1.5 mg/kg
Administration: P.o.
Result: Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.
Animal Model: FVB mice[1]
Dosage: 30 mg/kg
Administration: P.o.
Result: Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.
Animal Model: FVB mice[1]
Dosage: 0~100 mg/kg
Administration: P.o.
Result: Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.
분자량

465.41

화학식

C21H18D3Cl2N5OS
CAS No.
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(CC1)CC2=CC=C(C=C2)Cl)C3=CC(C4=CSC(NC([2H])([2H])[2H])=N4)=NC=C3Cl
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 100 mg/mL (214.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1486 mL 10.7432 mL 21.4864 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.84%

SDS (251 KB)

COA (246 KB) HNMR (134 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1486 mL 10.7432 mL 21.4864 mL 53.7161 mL
5 mM 0.4297 mL 2.1486 mL 4.2973 mL 10.7432 mL
10 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3716 mL
15 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5811 mL
20 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6858 mL
25 mM 0.0859 mL 0.4297 mL 0.8595 mL 2.1486 mL
30 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7905 mL
40 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
50 mM 0.0430 mL 0.2149 mL 0.4297 mL 1.0743 mL
60 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8953 mL
80 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.6715 mL
100 mM 0.0215 mL 0.1074 mL 0.2149 mL 0.5372 mL
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WNK-IN-11-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WNK-IN-11-d32123483-49-6WNK KinaseIsotope-Labeled CompoundsWith-no-lysine (WNK) kinaseorallyactiveselectivepotenteffectivecardiovascularhomeostasisInhibitorinhibitorinhibit

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Inquiry Information

상품명:
WNK-IN-11-d3
Cat. No.:
HY-112094S
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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