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α-Carotene 

Cat. No.: HY-113462
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α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables.

For research use only. We do not sell to patients.

α-Carotene Chemical Structure

α-Carotene Chemical Structure

CAS No. : 7488-99-5

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Description

α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2].

In Vitro

α-Carotene (0.5-2.5 μM; 24 hours) significantly increases protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells. AC (0.5-2.5 μM) significantly increases PAI-1 protein expression. α-Carotene (2.5 μM) also significantly inhibits integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family[2].
α-Carotene (0.5, 1, 2.5 μM; 48 hours) significantly and concentration-dependently inhibits invasion of LLC during 48 h of incubation[2].
α-Carotene (0.5, 1, 2.5 μM; 24 hours) significantly decreases activities of MMP-9, -2 and uPA in concentration-dependent manner in LLC cells[2].
α-Carotene (2, 5, 10 μM; 7 days) inhibits the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. α-Carotene (5 μM; 48 hours) halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Lewis lung carcinoma (LLC) cells
Concentration: 0.5, 1, 2.5 μM
Incubation Time: 24 hours
Result: Significantly increased protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells.
In Vivo

α-Carotene (5 mg/kg; oral; twice a week; for additional 3 weeks) alone significantly decreases lung metastasis without affecting primary tumor growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (4 weeks old; 20-25 g) with LLC cells[2]
Dosage: 5 mg/kg
Administration: Oral; twice a week; for additional 3 weeks
Result: Significantly decreased lung metastasis.
Molecular Weight

536.87

Formula

C₄₀H₅₆

CAS No.

7488-99-5

SMILES

CC1(C)[[email protected]@H](/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)=CCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-80°C

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Keywords:

α-CaroteneOthersprecursorvitaminAanti-metastaticadjuvantanti-canceryellow-orangedark-greenvegetablesLewislungcarcinomaLLCInhibitorinhibitorinhibit

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