2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 1-Oleoyl-sn-glycero-3-phosphocholine

1-Oleoyl-sn-glycero-3-phosphocholine  (Synonyms: 18:1 Lyso PC)

製品番号: HY-W140439 純度: 99.58%
COA 取扱説明書 Technical Support

1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation.1-Oleoyl-sn-glycero-3-phosphocholine exhibits reduced serum levels in mouse models of steatohepatitis, linked to hepatic Lpcat 1-4 up-regulation.

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1-Oleoyl-sn-glycero-3-phosphocholine

1-Oleoyl-sn-glycero-3-phosphocholine 構造式

CAS 番号 : 19420-56-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 59 在庫あり
Solution
10 mM * 1 mL in DMSO USD 59 在庫あり
Solid
1 mg $35 在庫あり
5 mg $51 在庫あり
10 mg $82 在庫あり
25 mg $160 在庫あり
50 mg $240 在庫あり
100 mg $360 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of 1-Oleoyl-sn-glycero-3-phosphocholine:

1-Oleoyl-sn-glycero-3-phosphocholine 関連抗体

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製品説明

1-Oleoyl-sn-glycero-3-phosphocholine (18:1 Lyso PC), a lysophospholipid, is a GPR82 inhibitor. 1-Oleoyl-sn-glycero-3-phosphocholine abrogates constitutive Gi-coupled GPR82 activity, shifts active/inactive equilibrium to inactive, suppresses Gi protein activation, increases cAMP production, and decreases GTPγS binding to Gαi proteins. 1-Oleoyl-sn-glycero-3-phosphocholine contributes to adipocyte lipolysis regulation.1-Oleoyl-sn-glycero-3-phosphocholine exhibits reduced serum levels in mouse models of steatohepatitis, linked to hepatic Lpcat 1-4 up-regulation[1][2].

体外実験

1-Oleoyl-sn-glycero-3-phosphocholine (1-10 μM; 30 min) increases cAMP production in Forskolin (HY-15371)-treated CHO-GPR82 cells in a concentration-dependent manner[1].
1-Oleoyl-sn-glycero-3-phosphocholine (3.3-10 μM; 10 min pre-incubation; 30 min [35S]GTPγS binding) concentration-dependently inhibits the constitutive [35S]GTPγS activity of GPR82 in CHO-GPR82 cell membrane fractions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Oleoyl-sn-glycero-3-phosphocholine 関連抗体
体内実験

1-Oleoyl-sn-glycero-3-phosphocholine shows that feeding male C57BL/6NCr mice an MCD diet causes a time-dependent reduction in serum 1-Oleoyl-sn-glycero-3-phosphocholine levels as NASH develops[2].
1-Oleoyl-sn-glycero-3-phosphocholine shows that intraperitoneal injection of GalN into male ob/ob mice induces steatohepatitis and causes a significant reduction in serum 1-Oleoyl-sn-glycero-3-phosphocholine levels relative to saline-injected controls[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

521.67

分子式

C26H52NO7P
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

Ethanol : 50 mg/mL (95.85 mM; Need ultrasonic)

H2O : 33.33 mg/mL (63.89 mM; Need ultrasonic)

DMSO : 10 mg/mL (19.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9169 mL 9.5846 mL 19.1692 mL
5 mM 0.3834 mL 1.9169 mL 3.8338 mL
10 mM 0.1917 mL 0.9585 mL 1.9169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL (1.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL (1.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.58%

COA (239 KB) HNMR (242 KB) RP-HPLC (243 KB) MS (72 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O / Ethanol 1 mM 1.9169 mL 9.5846 mL 19.1692 mL 47.9230 mL
5 mM 0.3834 mL 1.9169 mL 3.8338 mL 9.5846 mL
10 mM 0.1917 mL 0.9585 mL 1.9169 mL 4.7923 mL
15 mM 0.1278 mL 0.6390 mL 1.2779 mL 3.1949 mL
H2O / Ethanol 20 mM 0.0958 mL 0.4792 mL 0.9585 mL 2.3962 mL
25 mM 0.0767 mL 0.3834 mL 0.7668 mL 1.9169 mL
30 mM 0.0639 mL 0.3195 mL 0.6390 mL 1.5974 mL
40 mM 0.0479 mL 0.2396 mL 0.4792 mL 1.1981 mL
50 mM 0.0383 mL 0.1917 mL 0.3834 mL 0.9585 mL
60 mM 0.0319 mL 0.1597 mL 0.3195 mL 0.7987 mL
Ethanol 80 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5990 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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1-Oleoyl-sn-glycero-3-phosphocholine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oleoyl-sn-glycero-3-phosphocholine19420-56-518:1 Lyso PCEndogenous MetabolitecAMPGPR82primary hepatocytesCHO-GPR82 cellsob/ob miceadipocyte lipolysisGi proteinnonalcoholic steatohepatitisHEK-GPR82 cellsC57BL/6NCr miceInhibitorinhibitorinhibit

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製品名:
1-Oleoyl-sn-glycero-3-phosphocholine
製品番号:
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