2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. 2-(Tetradecylthio)acetic acid

2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator. 2-Tetradecylthio acetic acid induces hypolipidemia. 2-Tetradecylthio acetic acid reduces plasma lipids and enhances hepatic fatty acid oxidation in rodents. 2-Tetradecylthio acetic acid increases the expression of genes involved in fatty acid uptake, activation, accumulation, and oxidation.

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2-(Tetradecylthio)acetic acid

2-(Tetradecylthio)acetic acid Estructura química

No. CAS : 2921-20-2

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Other Forms of 2-(Tetradecylthio)acetic acid:

2-(Tetradecylthio)acetic acid Related Antibodies

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Descripciòn

2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator. 2-Tetradecylthio acetic acid induces hypolipidemia. 2-Tetradecylthio acetic acid reduces plasma lipids and enhances hepatic fatty acid oxidation in rodents. 2-Tetradecylthio acetic acid increases the expression of genes involved in fatty acid uptake, activation, accumulation, and oxidation[1][2].

Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
43 3
Compound: 3-Thia Fatty acid
Concentration required for inhibition of lipid synthesis in primary cultures of rat hepatocytes
Concentration required for inhibition of lipid synthesis in primary cultures of rat hepatocytes
[PMID: 15537362]
Hepatocyte IC50
43 3
Compound: 3-Thia Fatty acid
Concentration required for inhibition of lipid synthesis in primary cultures of rat hepatocytes
Concentration required for inhibition of lipid synthesis in primary cultures of rat hepatocytes
[PMID: 15537362]
Ensayo clínico
Peso molecular

288.49

Fòrmula

C16H32O2S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CSCCCCCCCCCCCCCC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : ≥ 2 mg/mL (6.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4663 mL 17.3316 mL 34.6632 mL
5 mM 0.6933 mL 3.4663 mL 6.9326 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4663 mL 17.3316 mL 34.6632 mL 86.6581 mL
5 mM 0.6933 mL 3.4663 mL 6.9326 mL 17.3316 mL
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2-(Tetradecylthio)acetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-(Tetradecylthio)acetic acid2921-20-2PPARPeroxisome proliferator-activated receptorsβ-Oxidationhypolipidemiafatty acid oxidationInhibitorinhibitorinhibit

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Nombre del producto:
2-(Tetradecylthio)acetic acid
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HY-139040
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