2. PI3K/Akt/mTOR NF-κB
  3. Akt NF-κB
  4. 3,4,5-Tricaffeoylquinic acid

3,4,5-Tricaffeoylquinic acid  (Synonyms: 3,4,5-triCQA)

製品番号: HY-N6588 純度: 98.15%
COA 取扱説明書 Technical Support

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.

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3,4,5-Tricaffeoylquinic acid

3,4,5-Tricaffeoylquinic acid 構造式

CAS 番号 : 86632-03-3

容量 価格（税別） 在庫状況 数量
1 mg $240 在庫あり
5 mg $680 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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3,4,5-Tricaffeoylquinic acid 関連抗体

Top Publications Citing Use of Products

Akt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Akt Akt1 Akt2 Akt3

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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製品説明

3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases[1][2].

体外実験

3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3,4,5-Tricaffeoylquinic acid 関連抗体

Cell Viability Assay[1]

Cell Line: Keratinocytes
Concentration: 15, 25 and 50 μM
Incubation Time: 24 hours
Result: Cell death was cell ∼4-5% at 15 and 25 μM, ∼9% at 50 μM.

Western Blot Analysis[1]

Cell Line: Keratinocytes
Concentration: 15 μM
Incubation Time: 20 min before 10 ng/mL TNF-α addition for 15 min
Result: Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
分子量

678.59

分子式

C34H30O15
CAS 番号
Appearance

Solid

Color

Yellow to brown

SMILES

O=C([C@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](OC(/C=C/C4=CC=C(O)C(O)=C4)=O)C1)O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (73.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4736 mL 7.3682 mL 14.7364 mL
5 mM 0.2947 mL 1.4736 mL 2.9473 mL
10 mM 0.1474 mL 0.7368 mL 1.4736 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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純度とドキュメンテーション

純度: 98.71%

COA (253 KB) HNMR (102 KB) RP-HPLC (192 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4736 mL 7.3682 mL 14.7364 mL 36.8411 mL
5 mM 0.2947 mL 1.4736 mL 2.9473 mL 7.3682 mL
10 mM 0.1474 mL 0.7368 mL 1.4736 mL 3.6841 mL
15 mM 0.0982 mL 0.4912 mL 0.9824 mL 2.4561 mL
20 mM 0.0737 mL 0.3684 mL 0.7368 mL 1.8421 mL
25 mM 0.0589 mL 0.2947 mL 0.5895 mL 1.4736 mL
30 mM 0.0491 mL 0.2456 mL 0.4912 mL 1.2280 mL
40 mM 0.0368 mL 0.1842 mL 0.3684 mL 0.9210 mL
50 mM 0.0295 mL 0.1474 mL 0.2947 mL 0.7368 mL
60 mM 0.0246 mL 0.1228 mL 0.2456 mL 0.6140 mL
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3,4,5-Tricaffeoylquinic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,4,5-Tricaffeoylquinic acid86632-03-33,4,5-triCQAAktNF-κBPKBProtein kinase BNuclear factor-κBNuclear factor-kappaBinflammatorykeratinocytescytoskeletonchromatinremodelingneuronalbonemorphogeneticagingInhibitorinhibitorinhibit

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製品名:
3,4,5-Tricaffeoylquinic acid
製品番号:
HY-N6588
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