2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. 4-Chlorokynurenine

4-Chlorokynurenine  (Synonyms: 4-Cl-KYN; AV-101)

Cat. No.: HY-108920 Purity: 99.94%
COA
SDS
Handling Instructions Technical Support

4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

4-Chlorokynurenine

4-Chlorokynurenine 화학구조

CAS No. : 153152-32-0

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

4-Chlorokynurenine Related Antibodies

Top Publications Citing Use of Products

View All iGluR Isoform Specific Products:

View All Isoforms
AMPA Receptor NMDA Receptor Kainate Receptor

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure[1][2][3].

IC50 & Target[1]

NMDA Receptor

 

In Vivo

4-Chlorokynurenine (25-125 mg/kg, i.p.) inhibits depression in depressed CD-1 mice[1].
4-Chlorokynurenine (50 mg/kg, i.p., 10, 30, 120 and 360 mins after quinolinate injection) prevents hippocampal neurotoxicity in quinolinate-induced neurotoxic rats models[2].
4-Chlorokynurenine (L-4-Chlorokynurenine) (50 mg/kg, i.p., 10, 30, 120 and 360 mins after kainate) attenuates kainate-induced seizures and neuronal loss in the rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Depressed CD-1 mice[1]
Dosage: 25 and 125 mg/kg
Administration: Intraperitoneally injection
Result: Decreased immobility time in the FST.
Rapidly decreased the latency to feed in the NSF arena.
Significantly decreased immobility time.
Animal Model: Kainate-induced rats[3]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection
Result: Intraperitoneally injection, 10, 30, 120 and 360 mins after kainite Delayed seizure onset and reduced the total time spent in seizure.
Prevented KA-induced lesions in the piriform cortex.
Provided protection of hippocampal pyramidal cells in area CA1.
Clinical Trial
분자량

242.66

화학식

C10H11ClN2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC([C@@H](N)CC(C1=C(C=C(C=C1)Cl)N)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 5 mg/mL (20.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1210 mL 20.6050 mL 41.2099 mL
5 mM 0.8242 mL 4.1210 mL 8.2420 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1210 mL 20.6050 mL 41.2099 mL 103.0248 mL
5 mM 0.8242 mL 4.1210 mL 8.2420 mL 20.6050 mL
10 mM 0.4121 mL 2.0605 mL 4.1210 mL 10.3025 mL
15 mM 0.2747 mL 1.3737 mL 2.7473 mL 6.8683 mL
20 mM 0.2060 mL 1.0302 mL 2.0605 mL 5.1512 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

4-Chlorokynurenine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Chlorokynurenine153152-32-04-Cl-KYN AV-101AV101AV 101AV-101iGluRIonotropic glutamate receptors7-Chlorokynurenic acidNMDADepressionSeizureInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
4-Chlorokynurenine
Cat. No.:
HY-108920
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.