153152-32-0
153152-32-0
Chemical Structure
4-Chlorokynurenine
Synonym(s): 4-Cl-KYN; AV-101
- CAS No.: 153152-32-0
- Formula:C10H11ClN2O3
- Molecular Weight:242.66
IUPAC Name: (S)-2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
InChIKey: HQLHZNDJQSRKDT-QMMMGPOBSA-N
SMILES: OC([C@@H](N)CC(C1=C(C=C(C=C1)Cl)N)=O)=O
Biological Activity: 4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
4-Chlorokynurenine | 99.94% | 4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Zanos P, et al. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. J Pharmacol Exp Ther. 2015 Oct;355(1):76-85. [Content Brief]
- [2]. Wu HQ, et al. Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus. Eur J Pharmacol. 2000 Mar 3;390(3):267-74. [Content Brief]
- [3]. Wu HQ, et al. L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Exp Neurol. 2002 Sep;177(1):222-32. [Content Brief]
