4-Chlorokynurenine
Based on 1 Customer Validation
4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 153152-32-0
- Formula: C10H11ClN2O3
- Molecular Weight:242.66
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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NMDA Receptor |
4-Chlorokynurenine (50 mg/kg, i.p., 10, 30, 120 and 360 mins after quinolinate injection) prevents hippocampal neurotoxicity in quinolinate-induced neurotoxic rats models[2].
4-Chlorokynurenine (L-4-Chlorokynurenine) (50 mg/kg, i.p., 10, 30, 120 and 360 mins after kainate) attenuates kainate-induced seizures and neuronal loss in the rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Depressed CD-1 mice[1]
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Dosage:25 and 125 mg/kg
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Administration:Intraperitoneally injection
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Result:Decreased immobility time in the FST.
Rapidly decreased the latency to feed in the NSF arena.
Significantly decreased immobility time.
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Animal Model:Kainate-induced rats[3]
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Dosage:50 mg/kg
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Administration:Intraperitoneally injection
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Result:Intraperitoneally injection, 10, 30, 120 and 360 mins after kainite Delayed seizure onset and reduced the total time spent in seizure.
Prevented KA-induced lesions in the piriform cortex.
Provided protection of hippocampal pyramidal cells in area CA1.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 153152-32-0
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Appearance Solid
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Molecular Weight 242.66
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Formula C10H11ClN2O3
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Color Off-white to light yellow
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SMILES
OC([C@@H](N)CC(C1=C(C=C(C=C1)Cl)N)=O)=O
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Synonyms
4-Cl-KYN; AV-101
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (20.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Zanos P, et al. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. J Pharmacol Exp Ther. 2015 Oct;355(1):76-85. [Content Brief]
[2]. Wu HQ, et al. Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus. Eur J Pharmacol. 2000 Mar 3;390(3):267-74. [Content Brief]
[3]. Wu HQ, et al. L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Exp Neurol. 2002 Sep;177(1):222-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.1210 mL | 20.6050 mL | 41.2099 mL | 103.0248 mL |
| 5 mM | 0.8242 mL | 4.1210 mL | 8.2420 mL | 20.6050 mL | |
| 10 mM | 0.4121 mL | 2.0605 mL | 4.1210 mL | 10.3025 mL | |
| 15 mM | 0.2747 mL | 1.3737 mL | 2.7473 mL | 6.8683 mL | |
| 20 mM | 0.2060 mL | 1.0302 mL | 2.0605 mL | 5.1512 mL |
4-Chlorokynurenine Related Classifications
HY-108920 Related Classifications
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