1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. 7-Chlorokynurenic acid

7-Chlorokynurenic acid (Synonyms: 7-CKA)

Cat. No.: HY-100811 Purity: 99.71%
Handling Instructions

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.

For research use only. We do not sell to patients.

7-Chlorokynurenic acid Chemical Structure

7-Chlorokynurenic acid Chemical Structure

CAS No. : 18000-24-3

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10 mM * 1 mL in DMSO USD 77 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 7-Chlorokynurenic acid:

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Description

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery[1][2].

IC50 & Target

Ki: 0.59 μM (reuptake of glutamate)[1]
IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)[2]

In Vivo

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response[3].

Molecular Weight

223.61

Formula

C₁₀H₆ClNO₃

CAS No.

18000-24-3

SMILES

O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (74.55 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4721 mL 22.3604 mL 44.7207 mL
5 mM 0.8944 mL 4.4721 mL 8.9441 mL
10 mM 0.4472 mL 2.2360 mL 4.4721 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (7.47 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.71%

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Keywords:

7-Chlorokynurenic acid7-CKAiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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7-Chlorokynurenic acid
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HY-100811
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