1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. 7-Chloro-4-hydroxyquinoline-2-carboxylic acid

7-Chloro-4-hydroxyquinoline-2-carboxylic acid (Synonyms: 7-Chlorokynurenic acid)

Cat. No.: HY-100811 Purity: 99.62%
Handling Instructions

7-Chloro-4-hydroxyquinoline-2-carboxylic acid (7-Chlorokynurenic acid) is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.

For research use only. We do not sell to patients.

7-Chloro-4-hydroxyquinoline-2-carboxylic acid Chemical Structure

7-Chloro-4-hydroxyquinoline-2-carboxylic acid Chemical Structure

CAS No. : 18000-24-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of 7-Chloro-4-hydroxyquinoline-2-carboxylic acid:

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Description

7-Chloro-4-hydroxyquinoline-2-carboxylic acid (7-Chlorokynurenic acid) is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex and also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM.

IC50 & Target

N-methyl-D-aspartate receptor[1]
Ki: 0.59 μM (reuptake of glutamate)[1]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (134.16 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4721 mL 22.3604 mL 44.7207 mL
5 mM 0.8944 mL 4.4721 mL 8.9441 mL
10 mM 0.4472 mL 2.2360 mL 4.4721 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

223.61

Formula

C₁₀H₆ClNO₃

CAS No.

18000-24-3

SMILES

O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.62%

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Product Name:
7-Chloro-4-hydroxyquinoline-2-carboxylic acid
Cat. No.:
HY-100811
Quantity:

7-Chloro-4-hydroxyquinoline-2-carboxylic acid

Cat. No.: HY-100811