2. Antibody-Drug Conjugate/ADC Related
  3. ADC Payloads
  4. ZD06519

ZD06519  (Synonyms: 7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin))

Art. -Nr.: HY-156513 Reinheit: 98.88%
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Handling Instructions Technical Support

ZD06519 (7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)) is a camptothecin (HY-16560) analogue and a topoisomerase I inhibitor. ZD06519 is an ADC cytotoxin with a strong bystander effect, inhibiting a variety of malignancies such as HER2-positive and FRα-overexpressing tumors. ZD06519 inhibits DNA cleavage, relaxation, and reconnection processes, inducing tumor cell death. ZD06519 can be used for ADC synthesis and cancer research.

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ZD06519

ZD06519 Chemische Struktur

CAS. Nr. : 2873460-17-2

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ZD06519 Related Antibodies

Top Publications Citing Use of Products

Alle ADC Payloads Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Beschreibung

ZD06519 (7-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)) is a camptothecin (HY-16560) analogue and a topoisomerase I inhibitor. ZD06519 is an ADC cytotoxin with a strong bystander effect, inhibiting a variety of malignancies such as HER2-positive and FRα-overexpressing tumors. ZD06519 inhibits DNA cleavage, relaxation, and reconnection processes, inducing tumor cell death. ZD06519 can be used for ADC synthesis and cancer research[1][2].

In Vitro

ZD06519 inhibits tumor cell viability with an IC50 of 1 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZD06519 Related Antibodies
In Vivo

ZD06519-ADC (3–8 mg/kg; iv; single dose) significantly inhibits tumor growth in CDX/PDX models such as JIMT-1 breast cancer, OV-90 ovarian cancer, and HT-29 colorectal cancer in immunodeficient mice, with complete tumor regression in some models without significant weight loss or organ toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB17.SCID mice (7-8 weeks old), JIMT-1 breast cancer CDX model[1]
Dosage: 3 mg/kg, 6 mg/kg, 8 mg/kg
Administration: Intravenous injection, single dose
Result: Resulted sustained tumor regression with no evidence of tumor regrowth at day 21 at 3 mg/kg. Mean tumor volume reduction exceeded 80% compared to vehicle control, with no significant adverse effects on body weight or organ histology.
The ADC induced a 75% reduction in mean tumor volume by day 10 at 6 mg/kg, with stable body weight and no signs of gastrointestinal or hematological toxicity.
Molekulargewicht

497.47

Formel

C25H24FN3O7
CAS. Nr.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1N2C(C(C(C2)=C(C3=C4)CNC(OCCO)=O)=NC3=CC(F)=C4C)=CC5=C1COC([C@]5(O)CC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (201.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0102 mL 10.0509 mL 20.1017 mL
5 mM 0.4020 mL 2.0102 mL 4.0203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.88%

SDS (252 KB)

COA (257 KB) HNMR (203 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0102 mL 10.0509 mL 20.1017 mL 50.2543 mL
5 mM 0.4020 mL 2.0102 mL 4.0203 mL 10.0509 mL
10 mM 0.2010 mL 1.0051 mL 2.0102 mL 5.0254 mL
15 mM 0.1340 mL 0.6701 mL 1.3401 mL 3.3503 mL
20 mM 0.1005 mL 0.5025 mL 1.0051 mL 2.5127 mL
25 mM 0.0804 mL 0.4020 mL 0.8041 mL 2.0102 mL
30 mM 0.0670 mL 0.3350 mL 0.6701 mL 1.6751 mL
40 mM 0.0503 mL 0.2513 mL 0.5025 mL 1.2564 mL
50 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0051 mL
60 mM 0.0335 mL 0.1675 mL 0.3350 mL 0.8376 mL
80 mM 0.0251 mL 0.1256 mL 0.2513 mL 0.6282 mL
100 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5025 mL
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ZD06519 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZD065192873460-17-27-Hydroxyethyl carbamate-(10Me-11F-Camptothecin)ZD 06519ZD-06519ADC PayloadsADC Cytotoxinsanti-FRα antibodyADCcytotoxinInhibitorinhibitorinhibit

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