ALX 40-4C Trifluoroacetate

Name: ALX 40-4C Trifluoroacetate
Brand: MedChemExpress
SKU: HY-P7061A
Rating: 4.5 (1 reviews)

製品番号: HY-P7061A 純度: 99.78%: Data Sheet SDS COA 取扱説明書
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ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a K_i of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC₅₀ of 2.9 μM.

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ALX 40-4C Trifluoroacetate 構造式

容量	価格（税別）	在庫状況	数量
1 mg	$100	在庫あり	Estimated Time of Arrival: December 31
5 mg	$250	在庫あり	Estimated Time of Arrival: December 31
10 mg	$400	在庫あり	Estimated Time of Arrival: December 31
25 mg	$600	お問い合わせ
50 mg		お問い合わせ
100 mg		お問い合わせ

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This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of ALX 40-4C Trifluoroacetate:

ALX 40-4C お問い合わせ

顧客検証

•Exp Cell Res. 2019 May 15;378(2):131-138. [Abstract]

CXCR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

生物活性
プロトコル
純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target^[1]^[3]

SDF-1-CXCR4

1 μM (Ki)

APJ receptor

2.9 μM (IC₅₀)

体外実験

ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, interacts with the second extracellular loop of CXCR4 and inhibits infection exclusively by blocking direct virus-CXCR4 interactions^[1]. ALX 40-4C shows potent anti HIV-1 effect, with EC₅₀s of 0.34 ± 0.04 μg/mL, 0.37 ± 0.01 μg/mL for HIV-1 NL4-3, NC10, and 0.18 ± 0.11 μg/mL, 0.06 ± 0.02 μg/mL for HIV-1 HXB2, HC43, respectively, and with a CC₅₀ (50% cytotoxic concentration) of 21 μg/mL. ALX 40-4C also exhibits potent activity against env-recombinant HIV, with EC₅₀s of 0.38 ± 0.01 μg/mL, 0.40 ± 0.0 μg/mL for HIV-1 NL4-3 env, NC10, and 1.34 ± 0.06 μg/mL, 1.02 ± 0.29 μg/mL for HIV-1 HXB2 env, HC43, and a CC₅₀ of 21 μg/mL^[2]. ALX 40-4C binds to APJ with an IC₅₀ of 2.9 μM. ALX 40-4C inhibits HIV-1 gp120/APJ-mediated cell membrane fusion, with an IC₅₀s of 3.41 μM and 3.1 μM for IIIB isolate and 89.6 isolate, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1464.74 (free base)

分子式

C₅₆H₁₁₃N₃₇O₁₀.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Ac-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-NH2

Sequence Shortening

Ac-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Arg}-NH2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 50 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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一般には略語で表示されます：C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.78%

Select Batch:

データシート (284 KB) SDS (252 KB)

COA (261 KB) RP-HPLC (265 KB) MS (101 KB) Elemental Analysis Report (120 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86. [Content Brief]

[2]. Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. [Content Brief]

[3]. Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. [Content Brief]

キナーゼ実験
^[3]

The stably transfected cells are harvested in PBS (Ca²⁺ and Mg²⁺ free) plus 0.5 nM EDTA and washed twice with PBS. Ligand binding experiments are performed using a single concentration (0.2 nM) of ¹²⁵I-Apelin-13 in the absence or presence of increasing concentrations of unlabeled Apelin-13 or ALX 40-4C in a final volume of 100 μL of binding buffer (50 nM Hepes, pH 7.4, 1 nM CaCl₂, 5 nM MgCl₂, 0.1% bovine serum albumin) containing 5 × 10⁵ cells. Nonspecific binding is determined by the addition of 1 μM unlabeled Apelin-13. Samples are incubated for 90 min at room temperature. The incubation is terminated by separating the cells from the binding buffer by centrifugation and washing once with 500 μL of cold binding buffer. Bound ligands are determined by counting gamma emissions. At least three independent experiments are performed^[3].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。こちらは参照専用です。

参考文献

[1]. Doranz BJ, et al. Safe use of the CXCR4 inhibitor ALX40-4C in humans. AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86. [Content Brief]

[2]. Armand-Ugón M, et al. HIV-1 resistance to the gp41-dependent fusion inhibitor C-34. Antiviral Res. 2003 Jul;59(2):137-42. [Content Brief]

[3]. Zhou N, et al. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1. Virology. 2003 Jul 20;312(1):196-203. [Content Brief]