2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AR7

AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 80306-38-3

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 86 在庫あり
Solution
10 mM * 1 mL in DMSO USD 86 在庫あり
Solid
5 mg $79 在庫あり
10 mg $132 在庫あり
25 mg $260 在庫あり
50 mg $420 在庫あり
100 mg $700 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 13 publication(s) in Google Scholar

Other Forms of AR7:

AR7 関連抗体

Top Publications Citing Use of Products

    AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82.  [Abstract]

    AR7 (10-20 μM; 24 h) dose-dependently decreased HK2 and PKM2 protein expression levels in A549 and H1299 cells.

    AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82.  [Abstract]

    AR7 (10-20 μM; 24 h) dose-dependently decreased ATG5 protein expression levels in A549 and H1299 cells.

    AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82.  [Abstract]

    AR7 (20 μM; 24 h) reversed the increased of HK2 and PKM2 in A549 cells induced by circPLCE1 overexpression.

    AR7 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2025 Mar 17;24(1):82.  [Abstract]

    AR7 (20 μM; 24 h) reversed the decrease in CMA activity induced by circPLCE1 overexpression, leading to a reduction in ATG5 expression in A549 cells.

    AR7 purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jun 12;13(1):62.  [Abstract]

    AR7 (50 μM) significantly decreased DYRK1A levels in NPC.

    AR7 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2020 Jul 23;528(2):276-284.  [Abstract]

    After treated with 1 μM AR7 for 3 days, the protein expression of CD11b, CEBPβ is detected by immunobloting and quantified.

    RAR/RXR アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    RXRα RXRβ RXRγ

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy[1].

    Cellular Effect
    Cell Line Type Value Description References
    HepG2 IC50
    10 μM
    Compound: 11
    Cytotoxicity against human HepG2 cells in hypoxic condition after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells in hypoxic condition after 48 hrs by MTT assay
    		[PMID: 19515559]
    体外実験

    Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2R1441G KI mutant MEFs[1].
    AR7 (10, 20, 30 uM; 12, 24 hours) has no effect on macroautophagy in NIH 3T3 cells[2].
    Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7 significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    AR7 関連抗体
    分子量

    257.71

    分子式

    C15H12ClNO
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 25 mg/mL (97.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8803 mL 19.4017 mL 38.8033 mL
    5 mM 0.7761 mL 3.8803 mL 7.7607 mL
    10 mM 0.3880 mL 1.9402 mL 3.8803 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.38%

    COA (246 KB) LCMS (90 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.8803 mL 19.4017 mL 38.8033 mL 97.0083 mL
    5 mM 0.7761 mL 3.8803 mL 7.7607 mL 19.4017 mL
    10 mM 0.3880 mL 1.9402 mL 3.8803 mL 9.7008 mL
    15 mM 0.2587 mL 1.2934 mL 2.5869 mL 6.4672 mL
    20 mM 0.1940 mL 0.9701 mL 1.9402 mL 4.8504 mL
    25 mM 0.1552 mL 0.7761 mL 1.5521 mL 3.8803 mL
    30 mM 0.1293 mL 0.6467 mL 1.2934 mL 3.2336 mL
    40 mM 0.0970 mL 0.4850 mL 0.9701 mL 2.4252 mL
    50 mM 0.0776 mL 0.3880 mL 0.7761 mL 1.9402 mL
    60 mM 0.0647 mL 0.3234 mL 0.6467 mL 1.6168 mL
    80 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2126 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    AR7 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AR780306-38-3AR 7AR-7RAR/RXRRetinoic acid receptorsRetinoid X receptorsretinoicacidreceptorCMAmacroautophagyInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    AR7
    製品番号:
    HY-101106
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.