2. Anti-infection
  3. Bacterial
  4. Cetylpyridinium chloride monohydrate

Cetylpyridinium (chloride monohydrate)  (Synonyms: Hexadecylpyridinium chloride monohydrate)

製品番号: HY-B1289 純度: 99.84%
COA 取扱説明書 Technical Support

Cetylpyridinium chloride monohydrate is a cationic quaternary ammonium compound used in some types of mouthwashes, toothpastes, and throat and nasal sprays as an antiseptic that kills bacteria and other microorganisms. Effectively prevents plaque and reduces gingivitis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Cetylpyridinium chloride monohydrate

Cetylpyridinium (chloride monohydrate) 構造式

CAS 番号 : 6004-24-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
500 mg $30 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Cetylpyridinium chloride monohydrate:

Cetylpyridinium (chloride monohydrate) 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Cetylpyridinium chloride monohydrate is a cationic quaternary ammonium compound used in some types of mouthwashes, toothpastes, and throat and nasal sprays as an antiseptic that kills bacteria and other microorganisms. Effectively prevents plaque and reduces gingivitis.

Cellular Effect
Cell Line Type Value Description References
Caco-2 CC50
0.66 μM
Compound: CETYLPYRIDINIUM CHLORIDE
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
10.21203/rs.3.rs-23951/v1
Caco-2 IC50
0.62 μM
Compound: CETYLPYRIDINIUM CHLORIDE
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
10.21203/rs.3.rs-23951/v1
体外実験

Cetylpyridinium chloride monohydrate (7.5-50 µg/mL, 5 minutes) disrupts the influenza viral envelope in a dose-dependent manner, leading to structural damage, increased membrane permeability, and nucleoprotein release[2].
Cetylpyridinium chloride monohydrate (10-250 µg/mL, 48 hours) exhibits dose-dependent cytotoxicity in MDCK cells, with a CC50 of 96 µg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cetylpyridinium (chloride monohydrate) 関連抗体

Cell Cytotoxicity Assay[2]

Cell Line: Madin-Darby Canine Kidney (MDCK) cells
Concentration: 10-250 µg/mL
Incubation Time: 10 minutes at room temperature, followed by 48 hours incubation at 37°C
Result: Led to a decrease in cell viability as the concentration increased. The 50% cytotoxic concentration (CC50) was 96 µg/mL.
体内実験

Cetylpyridinium chloride monohydrate (5 µL of 0.1% Cetylpyridinium chloride monohydrate, p.o., twice daily for 5 days) enhances survival and reduces influenza-associated morbidity and mortality in C57BL/6 mice infected with mouse-adapted Influenza A (PR8 strain)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice infected with mouse-adapted Influenza A (PR8 strain)[2]
Dosage: 5 µL of ARMS-1 (Cetylpyridinium chloride monohydrate-based formulation, 0.1% Cetylpyridinium chloride monohydrate w/v)
Administration: Oral gavage (p.o.), twice daily for 5 days
Result: Led to higher body weight maintenance in mice and significantly increased survival rates compared to the control group.
分子量

358.00

分子式

C21H40ClNO
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.O.[Cl-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 50 mg/mL (139.66 mM; Need ultrasonic)

DMSO : 20 mg/mL (55.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7933 mL 13.9665 mL 27.9330 mL
5 mM 0.5587 mL 2.7933 mL 5.5866 mL
10 mM 0.2793 mL 1.3966 mL 2.7933 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2 mg/mL (5.59 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2 mg/mL (5.59 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (279.33 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.84%

COA (240 KB) RP-HPLC (282 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.7933 mL 13.9665 mL 27.9330 mL 69.8324 mL
5 mM 0.5587 mL 2.7933 mL 5.5866 mL 13.9665 mL
10 mM 0.2793 mL 1.3966 mL 2.7933 mL 6.9832 mL
15 mM 0.1862 mL 0.9311 mL 1.8622 mL 4.6555 mL
20 mM 0.1397 mL 0.6983 mL 1.3966 mL 3.4916 mL
25 mM 0.1117 mL 0.5587 mL 1.1173 mL 2.7933 mL
30 mM 0.0931 mL 0.4655 mL 0.9311 mL 2.3277 mL
40 mM 0.0698 mL 0.3492 mL 0.6983 mL 1.7458 mL
50 mM 0.0559 mL 0.2793 mL 0.5587 mL 1.3966 mL
H2O 60 mM 0.0466 mL 0.2328 mL 0.4655 mL 1.1639 mL
80 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8729 mL
100 mM 0.0279 mL 0.1397 mL 0.2793 mL 0.6983 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cetylpyridinium chloride monohydrate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cetylpyridinium chloride6004-24-6Hexadecylpyridinium chlorideBacterialInfluenza A (PR8 strain)MDCK cellsAntibioticInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Cetylpyridinium chloride monohydrate
製品番号:
HY-B1289
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.