1. Anti-infection
  2. Bacterial
    HBV
  3. Cetylpyridinium chloride

Cetylpyridinium chloride 

Cat. No.: HY-B1464 Purity: >98.0%
Handling Instructions

Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC50 of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products.

For research use only. We do not sell to patients.

Cetylpyridinium chloride Chemical Structure

Cetylpyridinium chloride Chemical Structure

CAS No. : 123-03-5

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10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cetylpyridinium chloride, a cationic quaternary ammonium compound, is an anti-bacterial agent with broad-spectrum activity. Cetylpyridinium chloride is an effective anti-HBV capsid assembly inhibitor with an IC50 of 2.5 μM. Cetylpyridinium chloride is used in pesticides and various types of mouthwashes, and other personal care products[1][2].

IC50 & Target

IC50: 2.5 μM (HBV capsid assembly)[1]

In Vitro

Cetylpyridinium chloride interacts with dimeric viral nucleocapsid protein (known as core protein or HBcAg) specifically. Compared with other HBV inhibitors, Cetylpyridinium chloride achieves significantly better reduction of HBV particle number in HepG2.2.15 cell line. Cetylpyridinium chloride inhibits capsid assembly and leads to reduced HBV biogenesis[1].
Cetylpyridinium chloride is a safe antimicrobial agent with broad-spectrum activity for preventing biofilm formation and gingivitis[2].

In Vivo

Cetylpyridinium chloride (30 μg/kg; intramuscular injection; daily; for 3 days; male C57BL/6 mice) treatment inhibits HBV replication in mouse hydrodynamic model system[1].

Animal Model: Male C57BL/6 mice (6-week old) injected with the plasmid [1]
Dosage: 272 μg/kg/day
Administration: Intramuscular injection; daily; for 3 days
Result: Suppressed serum HBV DNA levels, decreased by 60% in day2 and 45% in day3 compared to the control.
Molecular Weight

339.99

Formula

C₂₁H₃₈ClN

CAS No.

123-03-5

SMILES

CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (294.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9413 mL 14.7063 mL 29.4126 mL
5 mM 0.5883 mL 2.9413 mL 5.8825 mL
10 mM 0.2941 mL 1.4706 mL 2.9413 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CetylpyridiniumBacterialHBVHepatitis B virusCapsidassemblyanti-bacterialreplicationcationicquaternaryammoniumpesticidesmouthwashesInhibitorinhibitorinhibit

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Cetylpyridinium chloride
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