2. Apoptosis
  3. Apoptosis
  4. Curcumol

Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.

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CAS No. : 4871-97-0

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg   견적 받기  
200 mg   견적 받기  

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고객리뷰

Based on 9 publication(s) in Google Scholar

Other Forms of Curcumol:

Curcumol Related Antibodies

Top Publications Citing Use of Products

    Curcumol purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Jun;17(6):7513-7520.  [Abstract]

    Curcumol alters the expression levels of genes in the EMT pathway. Western blot analysis of the expression of E cadherin protein. Western blot analysis of the expression of N cadherin protein.

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers[1].

    In Vitro

    Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae. Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3[2]
    . Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway[3]
    . Curcumol suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Curcumol Related Antibodies
    Clinical Trial
    분자량

    236.35

    화학식

    C15H24O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@@]1(C2)[C@H](C(C)C)C[C@]3(O1)[C@@H](C)CC[C@@]3([H])C2=C
    Structure Classification
    Initial Source
    선적

    Room temperature in continental US; may vary elsewhere.
    보관
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    용액&용해도
    In Vitro: 

    DMSO : ≥ 100 mg/mL (423.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.2310 mL 21.1551 mL 42.3101 mL
    5 mM 0.8462 mL 4.2310 mL 8.4620 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (10.58 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    순도&문서

    Purity: 99.50%

    SDS (393 KB)

    COA (258 KB) HNMR (230 KB) RP-HPLC (264 KB) MS (159 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.2310 mL 21.1551 mL 42.3101 mL 105.7753 mL
    5 mM 0.8462 mL 4.2310 mL 8.4620 mL 21.1551 mL
    10 mM 0.4231 mL 2.1155 mL 4.2310 mL 10.5775 mL
    15 mM 0.2821 mL 1.4103 mL 2.8207 mL 7.0517 mL
    20 mM 0.2116 mL 1.0578 mL 2.1155 mL 5.2888 mL
    25 mM 0.1692 mL 0.8462 mL 1.6924 mL 4.2310 mL
    30 mM 0.1410 mL 0.7052 mL 1.4103 mL 3.5258 mL
    40 mM 0.1058 mL 0.5289 mL 1.0578 mL 2.6444 mL
    50 mM 0.0846 mL 0.4231 mL 0.8462 mL 2.1155 mL
    60 mM 0.0705 mL 0.3526 mL 0.7052 mL 1.7629 mL
    80 mM 0.0529 mL 0.2644 mL 0.5289 mL 1.3222 mL
    100 mM 0.0423 mL 0.2116 mL 0.4231 mL 1.0578 mL
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    Curcumol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Curcumol4871-97-0(-)-CurcumolApoptosisbioactivesesquiterpenoidanticancerantimicrobialantifungalantiviralanti-inflammatorybreastInhibitorinhibitorinhibit

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    상품명:
    Curcumol
    Cat. No.:
    HY-N0104
    수량:
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    SAFETY DATA SHEET (SDS)

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