2. Apoptosis
  3. Ferroptosis
  4. DL-Buthionine-(S,R)-sulfoximine

DL-Buthionine-(S,R)-sulfoximine  (Synonyms: BSO; Buthionine sulfoximine; DL-ブチオニンスルホキシミン)

製品番号: HY-106376 純度: 99.82%
COA 取扱説明書 Technical Support

DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

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CAS 番号 : 5072-26-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 60 在庫あり
Solution
10 mM * 1 mL in Water USD 60 在庫あり
Solid
50 mg $55 在庫あり
100 mg $96 在庫あり
250 mg $155 在庫あり
500 mg $250 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

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カスタマーレビュー

Based on 35 publication(s) in Google Scholar

Other Forms of DL-Buthionine-(S,R)-sulfoximine:

DL-Buthionine-(S,R)-sulfoximine 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Proliferation/Viability Assay
WB
Bio/Physico-chemical Assay

    DL-Buthionine-(S,R)-sulfoximine purchased from MedChemExpress. Usage Cited in: Environ Int. 2025 Dec 30:207:110032.  [Abstract]

    DL-Buthionine-(S,R)-sulfoximine (BSO; 40 μM; 24 h). The protein expressions of ferroptosis-associated genes.

    DL-Buthionine-(S,R)-sulfoximine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 30;15(1):7522.  [Abstract]

    DL-Buthionine-(S,R)-sulfoximine (BSO; 0-10 μM; 48 h). To determine the effect of ferroptosis, HepG2 and SNU398 cells with or without SLC13A3 knockdown were treated with BSO for 48 h.

    DL-Buthionine-(S,R)-sulfoximine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Aug;10(22):e2206798.  [Abstract]

    DL-Buthionine-(S,R)-sulfoximine (BSO; 10 μM; 24 h). Cell death measurements in Huh7 cells treated with donafenib+GSK‐J4 with or without BSO.

    DL-Buthionine-(S,R)-sulfoximine purchased from MedChemExpress. Usage Cited in: Small. 2021 Dec;17(50):e2103984.  [Abstract]

    DL-Buthionine-(S,R)-sulfoximine (BSO; 500 μM; 12 h). Change of the AuNPs under different pre-treatments.

    DL-Buthionine-(S,R)-sulfoximine purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2020 Sep 18;48(16):9109-9123.  [Abstract]

    DL-Buthionine-(S,R)-sulfoximine (BSO; 10 μM; 2 h). The glutathione (GSH) levels in A549 cells were measured using the Micro Reduced Glutathione (GSH) Assay Kit 2 h after IR (8 Gy). Cells were pretreated with BSO for 2 h before IR.

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    製品説明

    DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

    IC50 & Target

    glutamylcysteine synthetase[1]
    体外実験

    Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    DL-Buthionine-(S,R)-sulfoximine 関連抗体
    体内実験

    Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    222.31

    分子式

    C8H18N2O3S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(C(N)CCS(CCCC)(=N)=O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    H2O : ≥ 50 mg/mL (224.91 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.4982 mL 22.4911 mL 44.9822 mL
    5 mM 0.8996 mL 4.4982 mL 8.9964 mL
    10 mM 0.4498 mL 2.2491 mL 4.4982 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (449.82 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.83%

    COA (244 KB) HNMR (155 KB) RP-HPLC (199 KB) MS (67 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [2]

    Mice[2]

    D,L-Buthionine-(S,R)-sulfoximine is dissolved in sterile 0.9% saline, filtered through a 0.2-p.m polysulfone membrane filter, and administered by 48-h continuous iv. infusion at a dose of 300 mg/kg/day and 600 mg/kg/day starting at 24 h before doxorubicin administration. In vivo GSH levels after treatment with D,L-Buthionine-(S,R)-sulfoximine at a dose of 300 mg/kg and 600 mg/kg for 24 h as an iv. continuous infusion in munine plasma and in tumor tissue of HT1080 and HT1080/DR4 xenografts is measured[2].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.4982 mL 22.4911 mL 44.9822 mL 112.4556 mL
    5 mM 0.8996 mL 4.4982 mL 8.9964 mL 22.4911 mL
    10 mM 0.4498 mL 2.2491 mL 4.4982 mL 11.2456 mL
    15 mM 0.2999 mL 1.4994 mL 2.9988 mL 7.4970 mL
    20 mM 0.2249 mL 1.1246 mL 2.2491 mL 5.6228 mL
    25 mM 0.1799 mL 0.8996 mL 1.7993 mL 4.4982 mL
    30 mM 0.1499 mL 0.7497 mL 1.4994 mL 3.7485 mL
    40 mM 0.1125 mL 0.5623 mL 1.1246 mL 2.8114 mL
    50 mM 0.0900 mL 0.4498 mL 0.8996 mL 2.2491 mL
    60 mM 0.0750 mL 0.3749 mL 0.7497 mL 1.8743 mL
    80 mM 0.0562 mL 0.2811 mL 0.5623 mL 1.4057 mL
    100 mM 0.0450 mL 0.2249 mL 0.4498 mL 1.1246 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    DL-Buthionine-(S,R)-sulfoximine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DL-Buthionine-(S,R)-sulfoximine5072-26-4Buthionine sulfoximine BSOFerroptosisInhibitorinhibitorinhibit

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    製品番号:
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