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D,L-Buthionine-(S,R)-sulfoximine hydrochloride (Synonyms: Buthionine sulfoximine (hydrochloride))

Cat. No.: HY-106376B
Handling Instructions

D,L-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

For research use only. We do not sell to patients.

D,L-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure

D,L-Buthionine-(S,R)-sulfoximine hydrochloride Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of D,L-Buthionine-(S,R)-sulfoximine hydrochloride:

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Description

D,L-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

IC50 & Target

Glutamylcysteine synthetase[1]

In Vitro

Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine[1].

In Vivo

Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors[2].

Molecular Weight

258.77

Formula

C₈H₁₉ClN₂O₃S

SMILES

OC(C(N)CCS(CCCC)(=N)=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 140 mg/mL (541.02 mM)

DMSO : ≥ 125 mg/mL (483.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8644 mL 19.3222 mL 38.6444 mL
5 mM 0.7729 mL 3.8644 mL 7.7289 mL
10 mM 0.3864 mL 1.9322 mL 3.8644 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
D,L-Buthionine-(S,R)-sulfoximine hydrochloride
Cat. No.:
HY-106376B
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