DL-Buthionine-(S,R)-sulfoximine hydrochloride (Synonyms: Buthionine sulfoximine hydrochloride; BSO hydrochloride)

Name: DL-Buthionine-(S,R)-sulfoximine hydrochloride
Brand: MedChemExpress
SKU: HY-106376B
Rating: 5.0 (36 reviews)

Cat. No.: HY-106376B Purity: 99.09%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
250 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 36 publication(s) in Google Scholar

Other Forms of DL-Buthionine-(S,R)-sulfoximine hydrochloride:

L-Buthionine-(S,R)-sulfoximine hydrochloride In-stock
DL-Buthionine-(S,R)-sulfoximine In-stock
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Standard) 견적 받기

36 Publications Citing Use of MCE DL-Buthionine-(S,R)-sulfoximine hydrochloride

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

: DL-Buthionine-(S,R)-sulfoximine hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Int. 2025 Dec 30:207:110032. [Abstract]; DL-Buthionine-(S,R)-sulfoximine (BSO; 40 μM; 24 h). The protein expressions of ferroptosis-associated genes.

: DL-Buthionine-(S,R)-sulfoximine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 30;15(1):7522. [Abstract]; DL-Buthionine-(S,R)-sulfoximine (BSO; 0-10 μM; 48 h). To determine the effect of ferroptosis, HepG2 and SNU398 cells with or without SLC13A3 knockdown were treated with BSO for 48 h.

: DL-Buthionine-(S,R)-sulfoximine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Aug;10(22):e2206798. [Abstract]; DL-Buthionine-(S,R)-sulfoximine (BSO; 10 μM; 24 h). Cell death measurements in Huh7 cells treated with donafenib+GSK‐J4 with or without BSO.

: DL-Buthionine-(S,R)-sulfoximine hydrochloride purchased from MedChemExpress. Usage Cited in: Small. 2021 Dec;17(50):e2103984. [Abstract]; DL-Buthionine-(S,R)-sulfoximine (BSO; 500 μM; 12 h). Change of the AuNPs under different pre-treatments.

: DL-Buthionine-(S,R)-sulfoximine hydrochloride purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2020 Sep 18;48(16):9109-9123. [Abstract]; DL-Buthionine-(S,R)-sulfoximine (BSO; 10 μM; 2 h). The glutathione (GSH) levels in A549 cells were measured using the Micro Reduced Glutathione (GSH) Assay Kit 2 h after IR (8 Gy). Cells were pretreated with BSO for 2 h before IR.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

IC₅₀ & Target

Glutamylcysteine synthetase^[1]

In Vitro

Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

분자량

258.77

화학식

C₈H₁₉ClN₂O₃S

Appearance

Solid

Color

White to off-white

SMILES

OC(C(N)CCS(CCCC)(=N)=O)=O.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

H₂O : 100 mg/mL (386.44 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8644 mL	19.3222 mL	38.6444 mL
5 mM	0.7729 mL	3.8644 mL	7.7289 mL
10 mM	0.3864 mL	1.9322 mL	3.8644 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (386.44 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.09%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (246 KB) HNMR (392 KB) RP-HPLC (252 KB) MS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Griffith OW, et al. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 1979 Aug 25;254(16):7558-60. [Content Brief]

[2]. Vanhoefer U, et al. d,l-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res. 1996 Dec;2(12):1961-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8644 mL	19.3222 mL	38.6444 mL	96.6109 mL
	5 mM	0.7729 mL	3.8644 mL	7.7289 mL	19.3222 mL
	10 mM	0.3864 mL	1.9322 mL	3.8644 mL	9.6611 mL
	15 mM	0.2576 mL	1.2881 mL	2.5763 mL	6.4407 mL
	20 mM	0.1932 mL	0.9661 mL	1.9322 mL	4.8305 mL
	25 mM	0.1546 mL	0.7729 mL	1.5458 mL	3.8644 mL
	30 mM	0.1288 mL	0.6441 mL	1.2881 mL	3.2204 mL
	40 mM	0.0966 mL	0.4831 mL	0.9661 mL	2.4153 mL
	50 mM	0.0773 mL	0.3864 mL	0.7729 mL	1.9322 mL
	60 mM	0.0644 mL	0.3220 mL	0.6441 mL	1.6102 mL
	80 mM	0.0483 mL	0.2415 mL	0.4831 mL	1.2076 mL
	100 mM	0.0386 mL	0.1932 mL	0.3864 mL	0.9661 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Buthionine-(S,R)-sulfoximineButhionine sulfoximineBSOFerroptosisInhibitorinhibitorinhibit

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DL-Buthionine-(S,R)-sulfoximine hydrochloride (Synonyms: Buthionine sulfoximine hydrochloride; BSO hydrochloride)

고객리뷰

Other Forms of DL-Buthionine-(S,R)-sulfoximine hydrochloride:

DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Antibodies

36 Publications Citing Use of MCE DL-Buthionine-(S,R)-sulfoximine hydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

DL-Buthionine-(S,R)-sulfoximine hydrochloride Related Classifications

Keywords:

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고객리뷰

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SAFETY DATA SHEET (SDS)

Request for HNMR Report