Deoxyarbutin

製品番号: HY-B1461 純度: 99.92%: Data Sheet SDS COA 取扱説明書
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Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity^[1][2][3].

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Deoxyarbutin 構造式

CAS 番号 : 53936-56-4

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 27	在庫あり	Estimated Time of Arrival: December 31
Solid
1 g	$25	在庫あり	Estimated Time of Arrival: December 31
5 g	$50	在庫あり	Estimated Time of Arrival: December 31
10 g	$75	在庫あり	Estimated Time of Arrival: December 31
25 g	$130	在庫あり	Estimated Time of Arrival: December 31
50 g	$180	在庫あり	Estimated Time of Arrival: December 31
100 g	$250	在庫あり	Estimated Time of Arrival: December 31
> 100 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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生物活性
純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target

Tyrosinase^[1].

体外実験

Deoxyarbutin (5-200 μM, 24 h) promotes melanoma cell apoptosis through p38 mediated mitochondrial related apoptosis pathway^[2].
Deoxyarbutin (0-1200 μM, 24 h) can restore mitochondrial function and enhance cell viability in mouse pancreatic acinar cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2].

Cell Line:	NIH/3T3、HS68、HK-2、L02、HLECs、HUVECs、B16F10、LL/2 cells
Concentration:	5-200 μM
Incubation Time:	24 h
Result:	Inhibited the proliferation of tumor cells, including B16F10 cells and LL/2 cells, and showed lower cytotoxicity to other normal cell lines.

Cell Viability Assay^[3].

Cell Line:	The mouse pancreatic acinar cell line 266-6 cells
Concentration:	0-1200 μM
Incubation Time:	24 h
Result:	Improved cell vitality in a dose-dependent manner.

体内実験

Deoxyarbutin (0-3 %; 6 weeks; Handling skin) has skin whitening effect in hairless pigmentary guinea pigs^[1].
Deoxyarbutin (50 mg/kg; once daily; 3 weeks; p.o.) exhibits anti-tumor activity and anti-tumor metastasis in melanoma mice^[2].
Deoxyarbutin (25, 50 mg/kg; 1 h, 3 h, and 6 h after modeling; i.p.) can alleviate severe acute pancreatitis in mice through the HtraA2/PGC-1 α pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A hairless pigmented (black) guinea pig model^[1].
Dosage:	0-3 %
Administration:	Handling skin; 6 weeks
Result:	Exhibited a dose-dependent skin whitening effect and re pigmentation of the skin after discontinuation of treatment.

Animal Model:	Male C57Bl/6 J mouse model of melanoma implanted with B16F10 cells^[2].
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.); once daily; 3 weeks
Result:	Inhibited tumor growth and lung metastasis.

Animal Model:	Male C57BL/6 mice receiving retrograde injection of 3.5% NaT into the pancreatic duct (25–30 g; 6–8 weeks)^[3].
Dosage:	25, 50 mg/kg
Administration:	Intraperitoneal injection (i.p.); 1 h, 3 h, and 6 h after modeling
Result:	Improved pancreatic histological features and histological scores for edema, inflammation, and necrosis.

分子量

194.23

分子式

C₁₁H₁₄O₃

CAS 番号

53936-56-4

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(OC2CCCCO2)C=C1

Structure Classification

Others

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (514.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1485 mL	25.7427 mL	51.4854 mL
5 mM	1.0297 mL	5.1485 mL	10.2971 mL
10 mM	0.5149 mL	2.5743 mL	5.1485 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.92%

Select Batch:

データシート (277 KB) SDS (393 KB)

COA (246 KB) HNMR (127 KB) RP-HPLC (303 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Boissy RE, et al. DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Exp Dermatol. 2005 Aug;14(8):601-8. [Content Brief]

[2]. Ma L, et al. Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Sci Rep. 2017 Aug 3;7(1):7197. [Content Brief]

[3]. Li Y, et al. Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway. Free Radic Res. 2022 Sep-Oct;56(9-10):651-665. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.1485 mL	25.7427 mL	51.4854 mL	128.7134 mL
	5 mM	1.0297 mL	5.1485 mL	10.2971 mL	25.7427 mL
	10 mM	0.5149 mL	2.5743 mL	5.1485 mL	12.8713 mL
	15 mM	0.3432 mL	1.7162 mL	3.4324 mL	8.5809 mL
	20 mM	0.2574 mL	1.2871 mL	2.5743 mL	6.4357 mL
	25 mM	0.2059 mL	1.0297 mL	2.0594 mL	5.1485 mL
	30 mM	0.1716 mL	0.8581 mL	1.7162 mL	4.2904 mL
	40 mM	0.1287 mL	0.6436 mL	1.2871 mL	3.2178 mL
	50 mM	0.1030 mL	0.5149 mL	1.0297 mL	2.5743 mL
	60 mM	0.0858 mL	0.4290 mL	0.8581 mL	2.1452 mL
	80 mM	0.0644 mL	0.3218 mL	0.6436 mL	1.6089 mL
	100 mM	0.0515 mL	0.2574 mL	0.5149 mL	1.2871 mL

Deoxyarbutin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxyarbutin53936-56-4TyrosinaseApoptosisorally activemitochondrial functionacinar cellB16F10melanomapancreatitisInhibitorinhibitorinhibit

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