Doxifluridine (Synonyms: 5'-DFUR; 5-Fluoro-5'-deoxyuridine; Ro 21-9738)

Name: Doxifluridine
Brand: MedChemExpress
SKU: HY-B0021
Rating: 5.0 (2 reviews)

製品番号: HY-B0021 純度: 99.44%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Doxifluridine 構造式

CAS 番号 : 3094-09-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 60	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$55	在庫あり	Estimated Time of Arrival: December 31
1 g	$86	在庫あり	Estimated Time of Arrival: December 31
5 g	$175	在庫あり	Estimated Time of Arrival: December 31
10 g	$280	在庫あり	Estimated Time of Arrival: December 31
50 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Doxifluridine:

Doxifluridine-d₂ お問い合わせ
Doxifluridine-d₃ お問い合わせ
Doxifluridine (Standard) お問い合わせ

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	2.2 x 10^-5 M Compound: 1	Concentration required for the 50% inhibition of growth of CCRF-CEM human leukemia cells in culture Concentration required for the 50% inhibition of growth of CCRF-CEM human leukemia cells in culture	[PMID: 7120290]
L1210	IC₅₀	3.6 x 10^-6 M Compound: 1	Concentration required for the 50% inhibition of growth of L1210 mouse leukemia cells in culture Concentration required for the 50% inhibition of growth of L1210 mouse leukemia cells in culture	[PMID: 7120290]
L1210	IC₅₀	3.0 x 10^-6 M Compound: 5'-dFUrd	Inhibition of cell growth of L1210 mouse Leukemia cells Inhibition of cell growth of L1210 mouse Leukemia cells	[PMID: 2967375]

体外実験

Doxifluridine (1-10 μM) inhibits angiogenesis by significantly inhibiting the expression of VEGF in FU-MMT-1 cells^[1].
Doxifluridine (1-100 μM) slightly increases the expression of TSP-1 at low dose (1 μM) and inhibits the expression of TSP-1 at high dose (100 μM) in FU-MMT-1 cells^[1].
Doxifluridine (100 μM) inhibits cell proliferation in HUVEC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Doxifluridine (61.55 mg/kg; Intragastric administration; Single dose) has anticancer activity in BALB cA Jcl-nu mice, and can significantly enhance anticancer activity in combination with TNP-470 (HY-101932)^[1].
Doxifluridine (200 mg/kg; Intraperitoneal injection; Single dose) can inhibit thymidine synthase activity in DMH-induced colon cancer mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

246.19

分子式

C₉H₁₁FN₂O₅

CAS 番号

3094-09-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)N([C@H]2[C@H](O)[C@H](O)[C@@H](C)O2)C=C(F)C1=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (406.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 100 mg/mL (406.18 mM; Need ultrasonic)

H₂O : 20 mg/mL (81.24 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0618 mL	20.3092 mL	40.6184 mL
5 mM	0.8124 mL	4.0618 mL	8.1237 mL
10 mM	0.4062 mL	2.0309 mL	4.0618 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 27.5 mg/mL (111.70 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.44%

Select Batch:

データシート (277 KB) SDS (393 KB)

COA (252 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Naganuma Y, et al. Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. Cancer Sci. 2011 Aug;102(8):1545-52. [Content Brief]

[2]. Berne M, et al. Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat. Cancer Invest. 1988;6(4):377-83. [Content Brief]

[3]. Di Bartolomeo M, et al. Integrated treatment with doxifluridine and radiotherapy in recurrent or primary unresectable rectal cancer. A feasibility study. Tumori. 1999 May-Jun;85(3):211-3. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO / DMF	1 mM	4.0618 mL	20.3092 mL	40.6184 mL	101.5459 mL
	5 mM	0.8124 mL	4.0618 mL	8.1237 mL	20.3092 mL
	10 mM	0.4062 mL	2.0309 mL	4.0618 mL	10.1546 mL
	15 mM	0.2708 mL	1.3539 mL	2.7079 mL	6.7697 mL
	20 mM	0.2031 mL	1.0155 mL	2.0309 mL	5.0773 mL
	25 mM	0.1625 mL	0.8124 mL	1.6247 mL	4.0618 mL
	30 mM	0.1354 mL	0.6770 mL	1.3539 mL	3.3849 mL
	40 mM	0.1015 mL	0.5077 mL	1.0155 mL	2.5386 mL
	50 mM	0.0812 mL	0.4062 mL	0.8124 mL	2.0309 mL
	60 mM	0.0677 mL	0.3385 mL	0.6770 mL	1.6924 mL
	80 mM	0.0508 mL	0.2539 mL	0.5077 mL	1.2693 mL
DMSO / DMF	100 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0155 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Doxifluridine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxifluridine3094-09-5Ro 21-9738 5-Fluoro-5'-deoxyuridine 5'-DFURThymidylate SynthaseCervical cancercolon cancer5-FU5-dFURBALB cA Jcl-nuFU-MMT-1Inhibitorinhibitorinhibit

最近チェックした製品:

製品名

カスタマ需要量 *

お名前 *

タイトル

メールアドレス *

電話番号 *

デパートメント

組纖名 *

市区町村

都道府県

国或いは地域 *

必ず会社名を記載ください。個人への返信は行いません。

備考

製品名

Lot #

お名前 *

メールアドレス *

電話番号 *

部門 *

組纖名 *

国或いは地域 *

備考

お名前
メール *

	Sorry, but the email address you supplied was invalid.

Doxifluridine (Synonyms: 5'-DFUR; 5-Fluoro-5'-deoxyuridine; Ro 21-9738)

カスタマーレビュー

Other Forms of Doxifluridine:

Doxifluridine 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Doxifluridine 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Doxifluridine Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

Request for HNMR Report

Request for HNMR Report