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  3. GDC-0927

GDC-0927 (Synonyms: SRN-927)

Cat. No.: HY-111484 Purity: 98.85% ee.: 99.88%
Handling Instructions

GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.

For research use only. We do not sell to patients.

GDC-0927 Chemical Structure

GDC-0927 Chemical Structure

CAS No. : 1642297-01-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 660 In-stock
Estimated Time of Arrival: December 31
5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 900 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3100 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GDC-0927:

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.

IC50 & Target

Estrogen receptor[1]

In Vivo

GDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (216.68 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1668 mL 10.8338 mL 21.6675 mL
5 mM 0.4334 mL 2.1668 mL 4.3335 mL
10 mM 0.2167 mL 1.0834 mL 2.1668 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

461.52

Formula

C₂₈H₂₈FNO₄

CAS No.

1642297-01-5

SMILES

OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)[[email protected]](C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.85% ee.: 99.88%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GDC-0927
Cat. No.:
HY-111484
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GDC-0927

Cat. No.: HY-111484