GDC-0927 Racemate
GDC-0927 Racemate (SRN-927 Racemate) is an estrogen receptor (ER) degrader that can effectively inhibit the activity of ER-α with an IC50 value of 0.2 nM and can be used in diseases related to estrogen receptors.
For research use only. We do not sell to patients.
- CAS No.: 1443983-36-5
- Formula: C28H28FNO4
- Molecular Weight:461.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.2 nM (ER-α)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.2 nM
Compound: 17h
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Antiproliferative activity against human MCF7 cells after 5 days by CellTiter-Glo assay
Antiproliferative activity against human MCF7 cells after 5 days by CellTiter-Glo assay
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[PMID: 30655946] |
| MCF7 | IC50 |
0.2 nM
Compound: 42
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Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
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[PMID: 35567964] |
| MCF7 | IC50 |
0.3 nM
Compound: 17h
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Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assay
Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assay
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[PMID: 30655946] |
GDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1443983-36-5
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Molecular Weight 461.52
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Formula C28H28FNO4
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SMILES
OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)C(C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1
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Synonyms
SRN-927 Racemate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GDC-0927 Racemate Related Classifications
HY-111484A Related Classifications
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