2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase
  4. GNE-140 racemate

GNE-140 racemate (Compound 28) is an external racemization mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and it is also an interconformational isomer of GNE-140 (HY-118241). GNE-140 racemate is also an effective lactate dehydrogenase (LDH) inhibitor, with the IC50 values for LDHA and LDHB being 9 nM and 30 nM respectively. GNE-140 racemate can be used in cancer research.

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GNE-140 racemate

GNE-140 racemate 화학구조

CAS No. : 1802977-61-2

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 9 publication(s) in Google Scholar

Other Forms of GNE-140 racemate:

GNE-140 racemate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

GNE-140 racemate (Compound 28) is an external racemization mixture of (R)-GNE-140 (HY-100742A) and (S)-GNE-140 (HY-100742B), and it is also an interconformational isomer of GNE-140 (HY-118241). GNE-140 racemate is also an effective lactate dehydrogenase (LDH) inhibitor, with the IC50 values for LDHA and LDHB being 9 nM and 30 nM respectively. GNE-140 racemate can be used in cancer research[1].

IC50 & Target

LDHA

 

Cellular Effect
Cell Line Type Value Description References
MIA PaCa-2 EC50
0.25 3
Compound: 32
Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation
Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation
[PMID: 25288186]
MIA PaCa-2 EC50
0.25 3
Compound: 32
Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation
Antiproliferative activity against human MIAPaCa2 cells assessed as inhibition of cell proliferation
[PMID: 25288186]
분자량

499.04

화학식

C25H23ClN2O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1SC2=CC=CC=C2Cl)NC(C3=CSC=C3)(C4=CC=C(N5CCOCC5)C=C4)CC1=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

DMSO : 20 mg/mL (40.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0038 mL 10.0192 mL 20.0385 mL
5 mM 0.4008 mL 2.0038 mL 4.0077 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.25%

SDS (393 KB)

COA (260 KB) LCMS (339 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0038 mL 10.0192 mL 20.0385 mL 50.0962 mL
5 mM 0.4008 mL 2.0038 mL 4.0077 mL 10.0192 mL
10 mM 0.2004 mL 1.0019 mL 2.0038 mL 5.0096 mL
15 mM 0.1336 mL 0.6679 mL 1.3359 mL 3.3397 mL
20 mM 0.1002 mL 0.5010 mL 1.0019 mL 2.5048 mL
25 mM 0.0802 mL 0.4008 mL 0.8015 mL 2.0038 mL
30 mM 0.0668 mL 0.3340 mL 0.6679 mL 1.6699 mL
40 mM 0.0501 mL 0.2505 mL 0.5010 mL 1.2524 mL
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GNE-140 racemate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GNE-1401802977-61-2GNE140GNE 140Lactate DehydrogenaseLDHracematemixtureglycolysisLDHAanti-cancerInhibitorinhibitorinhibit

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상품명:
GNE-140 racemate
Cat. No.:
HY-100742
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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