GPR120 modulator 2

製品番号: HY-50172 純度: 97.11%: Data Sheet SDS COA 取扱説明書
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GPR120 modulator 2 is a G protein coupled receptor 120 (GPR120) modulator extracted from patent US8394841B2, compound example F13. GPR120 modulator 2 can be used for the research of diseases associated with abnormal or deregulated GPR120, such as diabetes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

GPR120 modulator 2 構造式

CAS 番号 : 1050506-87-0

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$250	在庫あり	Estimated Time of Arrival: December 31
10 mg	$375	在庫あり	Estimated Time of Arrival: December 31
25 mg	$640	在庫あり	Estimated Time of Arrival: December 31
50 mg	$937	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1300	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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FFAR1 FFAR2 FFAR3 FFAR4

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

GPR120^[1]

分子量

387.88

分子式

C₂₀H₁₈ClNO₃S

CAS 番号

1050506-87-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCC1=CC=C(OCC2=NC(C3=CC=CC=C3Cl)=CS2)C=C1C

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (257.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5781 mL	12.8906 mL	25.7812 mL
5 mM	0.5156 mL	2.5781 mL	5.1562 mL
10 mM	0.2578 mL	1.2891 mL	2.5781 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3 mg/mL (7.73 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3 mg/mL (7.73 mM); Clear solution

This protocol yields a clear solution of ≥ 3 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (30.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 97.11%

Select Batch:

データシート (270 KB) SDS (251 KB)

COA (246 KB) RP-HPLC (250 KB) MS (71 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Robert Epple, et al. Compounds and methods for modulating G protein-coupled receptors. US8394841B2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5781 mL	12.8906 mL	25.7812 mL	64.4529 mL
	5 mM	0.5156 mL	2.5781 mL	5.1562 mL	12.8906 mL
	10 mM	0.2578 mL	1.2891 mL	2.5781 mL	6.4453 mL
	15 mM	0.1719 mL	0.8594 mL	1.7187 mL	4.2969 mL
	20 mM	0.1289 mL	0.6445 mL	1.2891 mL	3.2226 mL
	25 mM	0.1031 mL	0.5156 mL	1.0312 mL	2.5781 mL
	30 mM	0.0859 mL	0.4297 mL	0.8594 mL	2.1484 mL
	40 mM	0.0645 mL	0.3223 mL	0.6445 mL	1.6113 mL
	50 mM	0.0516 mL	0.2578 mL	0.5156 mL	1.2891 mL
	60 mM	0.0430 mL	0.2148 mL	0.4297 mL	1.0742 mL
	80 mM	0.0322 mL	0.1611 mL	0.3223 mL	0.8057 mL
	100 mM	0.0258 mL	0.1289 mL	0.2578 mL	0.6445 mL