1. Membrane Transporter/Ion Channel
  2. EAAT2

GT 949 

Cat. No.: HY-114381
Handling Instructions

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM.

For research use only. We do not sell to patients.

GT 949 Chemical Structure

GT 949 Chemical Structure

CAS No. : 460330-27-2

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10 mg USD 360 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].

IC50 & Target

EC50: 0.26±0.03 nM (EAAT2)[1]

In Vitro

GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1].
GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8952 mL 9.4758 mL 18.9516 mL
5 mM 0.3790 mL 1.8952 mL 3.7903 mL
10 mM 0.1895 mL 0.9476 mL 1.8952 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

527.66

Formula

C₃₀H₃₇N₇O₂

CAS No.

460330-27-2

SMILES

O=C1NC2=C(C=C(OC)C=C2)C=C1C(N3CCN(C4CCCCC4)CC3)C5=NN=NN5CCC6=CC=CC=C6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GT 949
Cat. No.:
HY-114381
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GT 949

Cat. No.: HY-114381