1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase

IC261 

Cat. No.: HY-12774 Purity: 98.97%
Data Sheet SDS Handling Instructions

IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.

For research use only. We do not sell to patients.
IC261 Chemical Structure

IC261 Chemical Structure

CAS No. : 186611-52-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
5 mg USD 108 In-stock
10 mg USD 192 In-stock
50 mg USD 816 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM. IC50 value: 16 μM [2] Target: CK1 in vitro: IC261 is a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. At low micromolar concentrations IC261 inhibits cytokinesis causing a transient mitotic arrest. IC261 selectively inhibits CK1 compared to other protein kinases by an ATP-competitive mechanism. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.2120 mL 16.0601 mL 32.1203 mL
5 mM 0.6424 mL 3.2120 mL 6.4241 mL
10 mM 0.3212 mL 1.6060 mL 3.2120 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

311.33

Formula

C₁₈H₁₇NO₄

CAS No.

186611-52-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 33 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
IC261
Cat. No.:
HY-12774
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