2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Progabide

Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.

For research use only. We do not sell to patients.

Progabide Chemical Structure

Progabide Chemical Structure

CAS No. : 62666-20-0

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Based on 1 publication(s) in Google Scholar

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Description

Progabide is a gamma-aminobutyric acid receptor (GABA) agonist.

IC50 & Target

GABA receptor[1]
In Vivo

Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

334.77

Formula

C17H16ClFN2O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N)CCC/N=C(C1=CC=C(Cl)C=C1)\C2=CC(F)=CC=C2O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (746.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9871 mL 14.9356 mL 29.8713 mL
5 mM 0.5974 mL 2.9871 mL 5.9743 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[1]

Male Wistar rats weighing 170 to 240 g are caged in groups of three under diurnal lighting conditions with free access to food and water. The rats are accustomed to handling (housing 1 per cage for 30 min, injecting with saline, 1 mL/100 g body weight) in the period of 7 days before the beginning of the experiment. Progabide is injected as a suspension in saline containing 0.1% Tween 80. Control rats are treated IP with the corresponding vehicle (1 mL/100 g body weight). Ether stress is performed and 15 min after the beginning of the stressful procedure the animals are sacrificed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9871 mL 14.9356 mL 29.8713 mL 74.6781 mL
5 mM 0.5974 mL 2.9871 mL 5.9743 mL 14.9356 mL
10 mM 0.2987 mL 1.4936 mL 2.9871 mL 7.4678 mL
15 mM 0.1991 mL 0.9957 mL 1.9914 mL 4.9785 mL
20 mM 0.1494 mL 0.7468 mL 1.4936 mL 3.7339 mL
25 mM 0.1195 mL 0.5974 mL 1.1949 mL 2.9871 mL
30 mM 0.0996 mL 0.4979 mL 0.9957 mL 2.4893 mL
40 mM 0.0747 mL 0.3734 mL 0.7468 mL 1.8670 mL
50 mM 0.0597 mL 0.2987 mL 0.5974 mL 1.4936 mL
60 mM 0.0498 mL 0.2489 mL 0.4979 mL 1.2446 mL
80 mM 0.0373 mL 0.1867 mL 0.3734 mL 0.9335 mL
100 mM 0.0299 mL 0.1494 mL 0.2987 mL 0.7468 mL
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Progabide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Progabide62666-20-0SL 76002SL76002SL-76002GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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