Pz-

By Targets:	5-HT Receptor (3) Apoptosis (1) Bacterial (1) Bcl-2 Family (3) Calcium Channel (1) Dopamine Receptor (1) Fungal (1) GABA Receptor (1) HIV (1) mAChR (1) Monoamine Oxidase (2) Phosphatase (1) PROTACs (3) Protease Activated Receptor (PAR) (1) RET (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (1) Neurological Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124634

PZ-2891 1 Publications Verification	Others	Neurological Disease
PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC₅₀s of 40.2 nM, 0.7 nM and 1.3 nM, respectively .

HY-U00437

Pz-1

RET VEGFR Cardiovascular Disease Cancer

Pz-1 is a potent RET and VEGFR2 inhibitor with IC₅₀s of less than 1 nM for both wild type kinases.

Pz-1	RET VEGFR	Cardiovascular Disease Cancer
Pz-1 is a potent RET and VEGFR2 inhibitor with IC₅₀s of less than 1 nM for both wild type kinases.

HY-155330

PZ-1922	5-HT Receptor Monoamine Oxidase	Neurological Disease
PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (K_i: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC₅₀: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test .

HY-155378

PZ-1190

5-HT Receptor Dopamine Receptor Neurological Disease

PZ-1190 is a multitarget ligand for serotonin and dopamine receptors with potential antipsychotic activity in rodents .

PZ-1190	5-HT Receptor Dopamine Receptor	Neurological Disease
PZ-1190 is a multitarget ligand for serotonin and dopamine receptors with potential antipsychotic activity in rodents .

HY-155330A

PZ-1922 free base	5-HT Receptor Monoamine Oxidase	Neurological Disease
PZ-1922 free base is a BBB-penetrable 5-HT6R/5-HT3R antagonist (K_i: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 free base reversibly inhibits MAO-B (pIC₅₀: 8.93). PZ-1922 free base reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 free base prevents Aβ-induced memory decline in the T-maze test .

HY-115718

PZ703b 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research .

HY-115718B

PZ703b hydrochloride 1 Publications Verification	PROTACs Apoptosis Bcl-2 Family	Cancer
PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research .

HY-107146

PZ-128 P1pal-7	Protease Activated Receptor (PAR)	Cardiovascular Disease Cancer
PZ-128 (P1pal-7), a cell-penetrating lipopeptide pepducin, is a first-in-class, specific and reversible protease-activated receptor-1 (PAR1) antagonist. PZ-128 targets the cytoplasmic surface of PAR1 and interrupts signaling to internally-located G (PAR1-G) proteins. PZ-128 has antiplatelet, anti-metastatic, anti-angiogenic and anticancer effects .

HY-120837

PZ-II-029	GABA Receptor	Neurological Disease
PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects .

HY-P4474

Pz-Pro-Leu-Gly-Pro-d-Arg	Bacterial	Infection
Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic substrate of bacterial collagenase. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to test bacterial collagenase activity .

HY-115718A

PZ703b TFA 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research .

HY-13750

Ebselen Maximum Cited Publications 11 Publications Verification SPI-1005; Pz-51; CCG-39161	Calcium Channel Virus Protease HIV Phosphatase	Infection Neurological Disease Inflammation/Immunology Cancer
Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker . Ebselen potently inhibits M ^pro (IC₅₀=0.67 μM) and COVID-19 virus (EC₅₀=4.67 μM) .Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity .

HY-126795

Aspergillin PZ

Fungal Infection

Aspergillin PZ is a novel isoindole-alkaloid from Aspergillus awamori. Aspergillin PZ induces conidia of P. oryzae to deform moderately .

Aspergillin PZ	Fungal	Infection
Aspergillin PZ is a novel isoindole-alkaloid from Aspergillus awamori. Aspergillin PZ induces conidia of P. oryzae to deform moderately .

HY-123063

Petromyzonol 5α-Petromyzonol; 5α-Pz	Others	Others
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant .

HY-105793

Mazaticol	mAChR	Neurological Disease
Mazaticol is an anticholinergic agent. Mazaticol blocks the muscarinic acetylcholine receptors and cholinergic nerve activity. Mazaticol is a potent 3H-QNB and 3H-PZ binding inhibitor, can bind to the M2 receptors with high affinity. Mazaticol exhibits inhibitory effects on dopamine uptake in the striatal nerve terminal. Mazaticol can be used for parkinsonian syndrome research .

Cat. No.	Product Name	Target	Research Area

HY-107146

PZ-128 P1pal-7	Protease Activated Receptor (PAR)	Cardiovascular Disease Cancer
PZ-128 (P1pal-7), a cell-penetrating lipopeptide pepducin, is a first-in-class, specific and reversible protease-activated receptor-1 (PAR1) antagonist. PZ-128 targets the cytoplasmic surface of PAR1 and interrupts signaling to internally-located G (PAR1-G) proteins. PZ-128 has antiplatelet, anti-metastatic, anti-angiogenic and anticancer effects .

HY-P4474

Pz-Pro-Leu-Gly-Pro-d-Arg	Bacterial	Infection
Pz-Pro-Leu-Gly-Pro-d-Arg is a synthetic substrate of bacterial collagenase. Pz-Pro-Leu-Gly-Pro-d-Arg can be used to test bacterial collagenase activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126795

Aspergillin PZ	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Fungal
Aspergillin PZ is a novel isoindole-alkaloid from Aspergillus awamori. Aspergillin PZ induces conidia of P. oryzae to deform moderately .

HY-123063

Petromyzonol 5α-Petromyzonol; 5α-Pz	Triterpenes Structural Classification Terpenoids Marine natural products Source classification Marine microorganism	Others
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant .

Species:	Human (1) Virus (2) Mouse (1)
Tag:	His (4)
Source:	HEK293 (3) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71292

	Serpin A10 Protein, Human (HEK293, His) Protein Z-Dependent Protease Inhibitor; Pz-Fependent Protease Inhibitor; PzI; Serpin A10; SERPINA10; ZPI	Human	HEK293
	Serpin A10 protein inhibits coagulation proteases, such as factor Xa, in the presence of PROZ, calcium, and phospholipids. It can also inhibit factor XIa without cofactors. Serpin A10 interacts with PROZ to exert its inhibitory effects on these coagulation factors. Serpin A10 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A10 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A10 Protein, Human (HEK293, His) is 423 a.a., with molecular weight of 55-80 kDa.

HY-P76639

	Serpin A10 Protein, Mouse (HEK293, His) Protein Z-Dependent Protease Inhibitor; Pz-Fependent Protease Inhibitor; PzI; Serpin A10; SERPINA10; ZPI	Mouse	HEK293
	Serpin A10 Protein, an inhibitor, regulates by inhibiting the activity of coagulation protease factor Xa in the presence of PROZ, calcium, and phospholipids. It also shows inhibitory effects on factor XIa even without cofactors, highlighting its versatility in modulating key components of the coagulation cascade. Serpin A10 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A10 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A10 Protein, Mouse (HEK293, His) is 427 a.a., with molecular weight of 60-80 kDa.

HY-P75120

	HA/Hemagglutinin Protein, H3N1 (ACS71642, sf9, His) Influenza A H3N1 (A/swine/Korea/Pz72-1/2006) Hemagglutinin / HA Protein (His)	Virus	Sf9 insect cells
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H3N1 (ACS71642, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of HA/Hemagglutinin Protein, H3N1 (ACS71642, sf9, His) is 530 a.a., with molecular weight of ~59.3 kDa.

HY-P74980

	HA1/Hemagglutinin Protein, H3N1 (ACS71642, HEK293, His) Influenza A H3N1 (A/swine/Korea/Pz72-1/2006) Hemagglutinin / HA1 Protein (His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA1/Hemagglutinin Protein, H3N1 (ACS71642, HEK293, His) is the recombinant Virus-derived HA1/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag. The total length of HA1/Hemagglutinin Protein, H3N1 (ACS71642, HEK293, His) is 345 a.a., with molecular weight of ~38 kDa.


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HY-P83028

CDC123 Antibody (YA2773)

C10orf7; CDC123; Cell division cycle 123; D123; HT 1080; Pz32
WB, IP, FC Human, Mouse, Rat

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