2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Monoamine Oxidase
  4. PZ-1922

PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test.

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PZ-1922 Chemical Structure

PZ-1922 Chemical Structure

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Other Forms of PZ-1922:

PZ-1922 Related Antibodies

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Description

PZ-1922 (Compound 16) is a BBB-penetrable 5-HT6R/5-HT3R antagonist (Ki: 17 nM, 0.45 nM for 5-HT6R/5-HT3R respectively). PZ-1922 reversibly inhibits MAO-B (pIC50: 8.93). PZ-1922 reverses Scopolamine (SCOP) (HY-N0296) induced memory deficits in the novel object recognition (NOR) test in rats. PZ-1922 prevents Aβ-induced memory decline in the T-maze test[1].

Molecular Weight

413.34

Formula

C22H22Cl2N4
SMILES

ClC1=CC(CN2C=CC3=C2C4=CC=CC=C4N=C3N5CCNCC5)=CC=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PZ-1922 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ-1922PZ1922PZ 19225-HT ReceptorMonoamine OxidaseSerotonin Receptor5-hydroxytryptamine ReceptorMAOScopolamineAβmemoryAlzheimer’sNOR testInhibitorinhibitorinhibit

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