2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. PZ-II-029

PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects.

For research use only. We do not sell to patients.

PZ-II-029 Chemical Structure

PZ-II-029 Chemical Structure

CAS No. : 164025-44-9

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PZ-II-029 Related Antibodies

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Description

PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects[1].

In Vivo

PZ-II-029 (1-10 mg/kg; i.p.; 30 min before Capsaicin instillation) inhibits central and peripheral trigeminal responses in a rat migraine model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-300 g; 8-10 weeks) induced by intra-cisternal (i.c.) instillation of Capsaicin[1].
Dosage: 1, 3, or 10 mg/kg
Administration: i.p.; 30 min before Capsaicin instillation
Result: Significantly attenuated the trigeminal cervical complex (TCC) neuronal activation and trigeminal ganglia (TG) calcitonin gene-related peptide immunoreactivity (CGRP-ir) elevation, and dural CGRP depletion induced by capsaicin.
Molecular Weight

321.33

Formula

C18H15N3O3
CAS No.
SMILES

O=C1N(C2=CC=C(OC)C=C2)N=C3C1=CNC4=C3C=CC(OC)=C4
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PZ-II-029 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PZ-II-029164025-44-9GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAA positive allosteric modulatoranti-migraine effectsα6β3γ2Inhibitorinhibitorinhibit

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HY-120837
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