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PZ-2891 

Cat. No.: HY-124634 Purity: 99.71%
Handling Instructions

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.

For research use only. We do not sell to patients.

PZ-2891 Chemical Structure

PZ-2891 Chemical Structure

CAS No. : 2170608-82-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively[1].

IC50 & Target

IC50: 40.2±4.4 nM (human PANK1β), 0.7±0.08 nM (human PANK2), 1.3±0.2 nM (human PANK3)[1]

In Vitro

PZ-2891 inhibits mouse pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 48.7±5.1 nM, 1.0±0.1 nM, and 1.9±0.2 nM, respectively[1].

Molecular Weight

349.43

Formula

C₂₀H₂₃N₅O

CAS No.

2170608-82-7

SMILES

N#CC1=NN=C(N2CCN(C(CC3=CC=C(C(C)C)C=C3)=O)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (214.64 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8618 mL 14.3090 mL 28.6180 mL
5 mM 0.5724 mL 2.8618 mL 5.7236 mL
10 mM 0.2862 mL 1.4309 mL 2.8618 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PZ-2891
Cat. No.:
HY-124634
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