2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-129043
    3-Formyl rifamycin 13292-22-3 98.50%
    3-Formyl rifamycin is an acid degradation product of the broad-spectrum antibiotic Rifampicin (HY-B0272). 3-Formyl rifamycin forms via acid hydrolysis of Rifampicin in an acidic environment.
    3-Formyl rifamycin
  • HY-129116
    SSAA09E1 433212-75-0 99.54%
    SSAA09E1 is a cathepsin L blocker (IC50: 5.33 μM).SSAA09E1 inhibits stages of viral entry. SSAA09E1 can be used for SARS-CoV infection research
    SSAA09E1
  • HY-129150
    Ganoderic acid TR 862893-75-2 98.0%
    Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC50 values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses.
    Ganoderic acid TR
  • HY-129197
    Stearyldiethanolamine 10213-78-2
    Stearyldiethanolamine is a typical amine-based surfactant used in development for antibacterial freshness-keeping film or antibacterial nonwoven fabric. Stearyldiethanolamine can be used as a collector towards the surfaces of quartz and malachite, to recover efficiently malachite from quartz. Stearyldiethanolamine can disrupt bacterial cell membrane with the alkyl chain, leading to irreversible damage and cell death.
    Stearyldiethanolamine
  • HY-129337
    Reveromycin A 134615-37-5 ≥99.0%
    Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity.
    Reveromycin A
  • HY-129558
    UK-1 151271-53-3 98%
    UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities. UK-1 also inhibits HCV replication.
    UK-1
  • HY-129861
    5'-Ethynyl-2'-deoxycytidine 69075-47-4 98.0%
    5'-Ethynyl-2'-deoxycytidine is an inhibitor for HSV, that inhibits the cytopathic effect of HSV-1 in primary rabbit kidney cell with a MIC of 0.2 μg/mL. 5'-Ethynyl-2'-deoxycytidine inhibits the proliferation of leukemia L1210 cell with an IC50 of 64.5 μg/mL.
    5'-Ethynyl-2'-deoxycytidine
  • HY-129959
    Aluminum phthalocyanine chloride 14154-42-8
    Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis.
    Aluminum phthalocyanine chloride
  • HY-131102
    Mequindox 13297-17-1 99.62%
    Mequindox is an antimicrobial agent. Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice.
    Mequindox
  • HY-131417
    cis-ACCP 777075-44-2
    cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases.
    cis-ACCP
  • HY-131605
    Ganciclovir triphosphate 86761-38-8 98%
    Ganciclovir triphosphate (GCV-TP) is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate has an IC50 of 0.01 μM against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition.
    Ganciclovir triphosphate
  • HY-131976
    BVDV-IN-1 345651-04-9 98.51%
    BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).
    BVDV-IN-1
  • HY-131981
    TP0586532 2427584-96-9 99.86%
    TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains. TP0586532 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TP0586532
  • HY-131989
    Desacetylcephapirin sodium 104557-24-6
    Desacetylcephapirin (Deacetylcephapirin) sodium is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen.
    Desacetylcephapirin sodium
  • HY-132600
    RG-101 1929655-04-8
    RG-101 is a hepatocyte targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122. miR-122 is an important host factor for hepatitis C virus (HCV) replication.
    RG-101
  • HY-132886
    SARS-CoV-2-IN-6 2725749-22-2 99.94%
    SARS-CoV-2-IN-6 is a SARS-CoV-2 3CLpro inhibitor that shows the most potent enzyme inhibitory IC50 value of 73 nM.
    SARS-CoV-2-IN-6
  • HY-133193
    Bis-propargyl-PEG5 185378-83-0 98.0%
    Bis-propargyl-PEG5 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG5 is used for the synthesis of carbohydrate receptors (SCRs) with anti-Zika activity. Bis-propargyl-PEG5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG5
  • HY-133246
    Monodes(N-carboxymethyl)valine Daclatasvir 1007884-60-7 98%
    Monodes(N-carboxymethyl)valine Daclatasvir (Daclatasvir Impurity A) is the main degradation product of Daclatasvir. Daclatasvir is a potent HCV NS5A protein inhibitor.
    Monodes(N-carboxymethyl)valine Daclatasvir
  • HY-133591
    Senecivernine 72755-25-0
    Senecivernine, a pyrrolizidine alkaloid isolated from Senecio species, exhibits a weakly mutagenic activity.
    Senecivernine
  • HY-133592
    Neoabietic acid 471-77-2 99.76%
    Neoabietic acid, an abietic-type acid, is a nature product that could be isolated from the oleoresin and rosin of Pinus palustris. Neoabietic acid is highly susceptible to mineral acid. Neoabietic acid has antibacterial activity.
    Neoabietic acid
Cat. No. Product Name / Synonyms Application Reactivity