2. Metabolic Enzyme/Protease
  3. MMP
  4. cis-ACCP

cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases.

For research use only. We do not sell to patients.

cis-ACCP Chemical Structure

cis-ACCP Chemical Structure

CAS No. : 777075-44-2

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Based on 1 publication(s) in Google Scholar

cis-ACCP Related Antibodies

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Description

cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases[1].

IC50 & Target

MMP-2

4 μM (IC50)

MMP-9

20 μM (IC50)

In Vitro

cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-ACCP Related Antibodies
In Vivo

cis-ACCP (i.p.; 50, 250, 500 mg/kg; daily for two weeks) shows no toxic effects and reduces metastasis formation in mice[1].
cis-ACCP (oral, i.v.,i.p.; 50, 150 mg/kg) only has distribution in the extracellular fluid[1].
Pharmacokinetic Parameters of cis-ACCP in rats[1].

PK parameter iv PO ip
AUC (min • µg/mL) 7637 79 2677
T1/2 (min) 18.8 126 108
Cmax(ng/mL) 306000 712 144000
CL (mL/min/kg) 6.9 - -
Tmax(min) - 17.4 0.5
Vss(mL/Kg) 186 - -
F (%) - 0.35 11.8
Fu (%) 83.9 2.2 48
Ttime over MIC (hr) >4 >6 24

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL mice[1]
Dosage: 50, 250, 500 mg/kg; 12.5 to 50 mg/kg
Administration: Oral, intraperitoneal, daily for two weeks; daily, 21 days
Result: Showed no toxic effects and showed 50-85% inhibition of metastasis formation, depending on the dose.
Animal Model: Rats[1]
Dosage: 50, 150 mg/kg
Administration: Oral, intravenous, intraperitoneal
Result: Showed 84% of the intravenously administered drug are excreted unchanged.
Molecular Weight

222.18

Formula

C7H15N2O4P
CAS No.
SMILES

OP(O)(C(N[C@H]1[C@@H](N)CCCC1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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cis-ACCP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-ACCP777075-44-2MMPMatrix metalloproteinasesoralmatrix metalloproteinases (MMPs)MMP-2MMP-9chronic diseasesInhibitorinhibitorinhibit

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