2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118565
    Rhizocarpic acid 18463-11-1 98%
    Rhizocarpic acid (Compound 2) is a secondary metabolite of lichen. Rhizocarpic acid effectively inhibits the growth of bacteria, such as Bacillus subtilis and Staphylococcus aureus, as well as murine myeloma NS-1 cells. Rhizocarpic acid is an antioxidant and an insect antifeedant with an ED50 of 71 μmol/g dry weight against neonate larvae of the Egyptian cotton leaf worm Spodoptera littoralis.
    Rhizocarpic acid
  • HY-118593
    A2315A 58717-24-1 98%
    A2315A (Madumycin II) is an alanine-containing streptogramin A antibiotic. A2315A is a potent peptidyl transferase center (PTC) inhibitor. A2315A inhibits the ribosome prior to the first cycle of peptide bond formation.
    A2315A
  • HY-118621
    JCP174 126062-19-9 98%
    JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase.
    JCP174
  • HY-118632
    BILR 355 380378-81-4 98%
    BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward HIV-1 reverse transcriptase (RT). BILR 355 can be used for HIV infections research.
    BILR 355
  • HY-118745
    A-73209 136451-98-4 98%
    A-73209 is an orally active and potent antivirus agent against VZV, HSV-1, and HSV-2. A-73209 is an Oxetanocin derivative and can be utilized in antivirus research.
    A-73209
  • HY-118797
    Malioxamycin 73020-27-6 98%
    Malioxamycin is an antibiotic that inhibits Gram-negative bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls and promoting the formation of spheroplasts.
    Malioxamycin
  • HY-118847
    Antifungal agent 86 327077-97-4 98%
    Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC50: 0.4-0.8 μM).
    Antifungal agent 86
  • HY-118865
    Piperaquine tetraphosphate 911061-10-4 98%
    Piperaquine tetraphosphate is a potent antimalaria agent. Piperaquine tetraphosphate shows inhibition for chloroquine-sensitive and the chloroquine-resistant isolates. Piperaquine tetraphosphate in combination with dihydroartemisinin has the potential for the research of chloroquine-resistant malaria.
    Piperaquine tetraphosphate
  • HY-118951
    VU0038882 429653-28-1 98%
    VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) .
    VU0038882
  • HY-118989
    Ajugalactone 42975-12-2 98%
    Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both ecdysone (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation.
    Ajugalactone
  • HY-118992
    Aurodox 12704-90-4 98%
    Aurodox (X 5108) is an antibiotic obtained from a streptomyces variant, Aurodox can against a number of gram-positive bacteria. Aurodox shows a very low toxicity in mice and promoted poultry growth.
    Aurodox
  • HY-119011
    Pivampicillin 33817-20-8 98%
    Pivampicillin is a penicillin antibiotic. Pivampicillin is a prodrug of Ampicillin (HY-B0522).
    Pivampicillin
  • HY-119022
    MAC-0547630 950386-41-1 98%
    MAC-0547630 is a potent inhibitor of undecaprenyl diphosphate synthase (UppS), with IC50s of 0.05 μM and 1.6 μM for UppSBS and UppSBA, respectively. MAC-0547630 is active against B. subtilis in vitro (MIC 0.1 ng/mL).
    MAC-0547630
  • HY-119132
    RWJ-416457 474016-05-2 98%
    RWJ-416457 is an orally active antibacterial agent targeting 23S rRNA ribosome. RWJ-416457 is promising for research of Gram-positive bacterial infections.
    RWJ-416457
  • HY-119151
    GS-9191 859209-84-0 98%
    GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection.
    GS-9191
  • HY-119161
    VX-759 478025-29-5 98%
    VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C.
    VX-759
  • HY-119202
    (S)-BMS-378806 357263-14-0 98%
    (S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA.
    (S)-BMS-378806
  • HY-119210
    ZINC04177596 364052-84-6 98%
    ZINC04177596 is a potent HIV-negative factor (HIV-Nef) protein inhibitor. Nef is an accessory gene product of HIV and has an imperative role in viral replication and AIDS pathogenesis.
    ZINC04177596
  • HY-119213
    BMY-27709 99390-76-8 98%
    BMY-27709 is an influenza virus growth inhibitor with an IC50 value of 3-8 μM against A/WSN/33 virus growth, and also exhibits inhibitory activity against some subtypes of influenza viruses. BMY-27709 acts early in the course of H1 and H2 virus infections, and exhibits antiviral activity through inhibition of hemagglutinin proteins. However, BMY-27709 has no effect on H3 subtype viruses and influenza B/Lee/40 viruses.
    BMY-27709
  • HY-119405
    Niddamycin 20283-69-6 98%
    Niddamycin, a macrolide antibiotic, binds 50S ribosomal subunits to inhibit protein synthesis.
    Niddamycin
Cat. No. Product Name / Synonyms Application Reactivity