(S)-BMS-378806
(S)-BMS-378806 ((S)-BMS-806) is an orally bioavailable HIV-1 inhibitor with activity against gp120-CD4 interactions. (S)-BMS-378806 exhibits micromolar inhibition of HIV-1 gp120-CD4 binding. The design and synthesis of (S)-BMS-378806 was based on a comprehensive study of protein-ligand interactions, which guided the identification and design of novel symmetrical N,N'-disubstituted aminoureas and thioureas. (S)-BMS-378806, synthesized in aqueous media using microwave irradiation, was validated for its inhibitory activity in HIV-1 gp120-CD4 capture ELISA.
For research use only. We do not sell to patients.
- CAS No.: 357263-14-0
- Formula: C22H22N4O4
- Molecular Weight:406.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 357263-14-0
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Molecular Weight 406.43
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Formula C22H22N4O4
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SMILES
C[C@@H]1N(CCN(C1)C(C2=CC=CC=C2)=O)C(C(C3=CNC4=NC=CC(OC)=C43)=O)=O
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Synonyms
(S)-BMS-806
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-BMS-378806 Related Classifications
HY-119202 Related Classifications
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