VX-759 (Synonyms: VCH-759)

Cat. No.: HY-119161: Data Sheet Handling Instructions
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VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C.

For research use only. We do not sell to patients.

VX-759 Chemical Structure

CAS No. : 478025-29-5

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Description

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C^[1].

IC₅₀ & Target

RNA Polymerase

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	48 μM Compound: 2	Cytotoxicity against human HuH7 cells by WST-1 assay Cytotoxicity against human HuH7 cells by WST-1 assay	[PMID: 20584604]
Huh-7	CC₅₀	> 50000 nM Compound: 21	Cytotoxicity against human HuH7 cells by MTT assay Cytotoxicity against human HuH7 cells by MTT assay	[PMID: 19877603]
Huh-7	CC₅₀	>= 20 μM Compound: 9	Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay	[PMID: 24144213]
Huh-7	EC₅₀	0.23 μM Compound: 2	Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay	[PMID: 20584604]
Huh-7	EC₅₀	1400 nM Compound: 21	Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay	[PMID: 19877603]
Huh-7	EC₅₀	170 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	2100 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	593 nM Compound: 9	Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
MT4	CC₅₀	> 20 μM Compound: 9	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

Clinical Trial

Molecular Weight

385.52

Formula

C₂₂H₂₇NO₃S

CAS No.

478025-29-5

SMILES

O=C([C@@H]1CC[C@H](CC1)C)N(C2=C(SC(C3=CC=CC=C3)=C2)C(O)=O)C(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cooper C, et al. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol. 2009 Jul;51(1):39-46. doi: 10.1016/j.jhep.2009.03.015. Epub 2009 Apr 23. [Content Brief]

VX-759 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VX-759478025-29-5VCH-759VX759VX 759VCH759VCH 759DNA/RNA SynthesisHCVHCV ProteaseHepatitis C virusHCV NS5B RNA-dependent RNA polymeraseInhibitorinhibitorinhibit

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VX-759 (Synonyms: VCH-759)

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References

Customer Review

VX-759 Related Classifications

Molarity Calculator

Dilution Calculator