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Cat. No.: HY-118847

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Antifungal agent 86

Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC₅₀: 0.4-0.8 μM).

For research use only. We do not sell to patients.

CAS No.: 327077-97-4
Formula: C₂₁H₂₂N₂OS
Molecular Weight:350.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Antifungal agent 86 Chemical Structure

CAS No.: 327077-97-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC₅₀: 0.4-0.8 μM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
P388D1	IC₅₀	>40 μM Compound: 41F5	Cytotoxicity against mouse P388D1 cells assessed as reduction in cell viability after 72 hrs by resazurin-based fluorescence assay Cytotoxicity against mouse P388D1 cells assessed as reduction in cell viability after 72 hrs by resazurin-based fluorescence assay	[PMID: 29580849]
P388D1	IC₅₀	54 μM Compound: 9d, 41F5	Cytotoxicity against mouse P388D1 HepG2 cells after 48 hrs by crystal violet staining method Cytotoxicity against mouse P388D1 HepG2 cells after 48 hrs by crystal violet staining method	[PMID: 25543205]

Chemical Information

CAS No. 327077-97-4
Molecular Weight 350.48
Formula C₂₁H₂₂N₂OS
SMILES

O=C(NC1=NC=C(S1)CC2=C3C=CC=CC3=CC=C2)C4CCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khalil A, et al. Design, synthesis, and biological evaluation of aminothiazole derivatives against the fungal pathogens Histoplasma capsulatum and Cryptococcus neoformans. Bioorg Med Chem. 2015 Feb 1;23(3):532-47. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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