1. Anti-infection
  2. Bacterial
  3. VU0038882

VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) .

For research use only. We do not sell to patients.

VU0038882 Chemical Structure

VU0038882 Chemical Structure

CAS No. : 429653-28-1

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Description

VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) [1].

In Vitro

VU0038882 (‘882) (40 μM) exposure leads to accumulation of CPIII in S. aureus[1].
VU0038882 (0-10 μM) activates CgoX from Gram-Positive bacteria in vitro[1].
VU0038882 (50 μM) induces photosensitivity in Gram-positive pathogens[1].
VU0038882 leads to massive heme accumulation resulting in HssRS activation in S. aureus[1].
VU0038882 leads to photosensitization of Gram-positive bacteria, reducing bacterial burdens in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.29

Formula

C17H12N2O2

CAS No.
SMILES

OC1=C2C=CC=CC2=CC=C1C3=NNC(C4=CC=CO4)=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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VU0038882 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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VU0038882
Cat. No.:
HY-118951
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