Infection

RSV-IN-3 (Compound 1) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-3 shows anti-RSV activity (EC₅₀ = 32.70 μM).

Ansatrienin A is an antifungal antibiotic that can be isolated from Streptomyces collinus.

Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.

MDI-403 is a retinoic acid receptor (RAR) agonist with an EC₅₀ value of less than 1 μM. MDI-403 exhibits significant antiviral activity against SARS-CoV-2, and can dose-dependently inhibit the expression of viral nucleoprotein (NP) and reduce the proportion of infected cells. MDI-403 mainly acts during the virus invasion stage. MDI-403 can be used in research on anti-SARS-CoV-2.

DSPE-PEG3400-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

Xalnesiran (RO7445482) is a small interfering RNA molecule that targets a conserved region of the
hepatitis B virus (HBV) genome. Xalnesiran can be used for the research of chronic hepatitis B infection.

Tralomethrin is a pyrethroid insecticide used to control a wide range of pests in agriculture and public health.

DCN-83, an anti-leishmania agent, is most potent against the amastigote form with an IC₅₀ of 0.71 μM. DCN-83 has the potential to cross the blood-brain barrier and central nervous system.

ChlaDUB1-IN-2 (Compound 27a) is the inhibitor for Chlamydia trachomatis deubiquitinase ChlaDUB1 with an IC₅₀ of 0.97 μM. ChlaDUB1-IN-2 inhibits the inclusion body formation of C. trachomatis with an IIC₅₀ of 25.6 μg/mL.

JAK-IN-39 (compound 11) is a JAK inhibitor that suppresses JAK1, JAK2, JAK3 with IC₅₀ values of 0.05, 1.18, and 0.03 nM, respectively. JAK-IN-39 can inhibit the viability of TF-1 cells and also suppress the production of lymphocyte TNFα and INFγ in vitro.

Faldaprevir-d₇ is deuterium labeled Faldaprevir.

L-640876 is a broad-spectrum and orally active lactam antimicrobial agent. L-640876 showa MIC90 of 0.125 pg/mL for the E. coli strains, 2 /mg/mL for the S.choleraerai strains and 4 pg/mL for the S. typhinwrium strains.

Dabequin phosphate is an antimalarial agent, that exhibits inhibitory activity against Plasmodium falciparum.

Lactucin (Standard) is the analytical standard of Lactucin. This product is intended for research and analytical applications. Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[4].

Sirt1/CXCR3-IN-1 is a dual Sirt1/CXCR3 inhibitor with an IC₅₀ of 0.77 μM against Sirt1. Sirt1/CXCR3-IN-1 inhibits dengue virus replication, upregulates the expression of interferon-stimulated genes, and enhances the antiviral defense capacity of the host. Sirt1/CXCR3-IN-1 suppresses CXCR3-mediated T cell chemotaxis and cytokine release, thereby reducing immune activation and inflammatory responses. Sirt1/CXCR3-IN-1 is applicable to research related to dengue virus infection.

Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀ of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease.

Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections.

Linarin (Standard) is the analytical standard of Linarin. This product is intended for research and analytical applications. Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer.

EIDD 1931-¹³C,¹⁵N₂ (β-D-N4-Hydroxycytidine-¹³C,¹⁵N₂) is the ¹³C- and ¹⁵N-labeled EIDD 19312 (HY-125033). EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent?anti-virus agent. EIDD-1931 effectively inhibits the replication activity of?venezuelan equine encephalitis?virus (VEEV),?Chikungunya?virus (CHIKV) and?hepatitis?C virus (HCV)

Neocnidilide is an alkylphthalide, which has the activity of inhibiting the growth of mycotoxin-producing fungi. Neocnidilide also has larvicidal activity against D. melanogaster with a LC₅₀ value of 9.9 μmol/mL.