2. Anti-infection
  3. Dengue Virus
  4. Peridinin

Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against DENV NS2B/NS3 protease and all dengue virus serotypes (DENV-1, DENV-2, DENV-3, DENV-4). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection.

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Peridinin

Peridinin Chemical Structure

CAS No. : 33281-81-1

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Peridinin Related Antibodies

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Description

Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against DENV NS2B/NS3 protease and all dengue virus serotypes (DENV-1, DENV-2, DENV-3, DENV-4). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection[1].

In Vitro

Peridinin (Compound 9) (72 h) potently inhibits four dengue virus serotypes in Huh-7 cells, with the strongest activity against DENV-2 (EC50 = 4.50 μM), and reduces viral titer by 2 log10 at a concentration of 10 μM. The EC50 values against DENV-1, DENV-3, and DENV-4 are 7.62 μM, 5.84 μM, and 6.51 μM, respectively[1].
Peridinin (72 h) exhibits low cytotoxicity in Huh-7 cells (CC50 = 132.55 μM), resulting in an exceptionally high selectivity index of >29.5 for its anti-DENV-2 activity[1].
Peridinin (3 days) inhibits DENV NS3 protease activity in Huh-7 cells, with an EC50 of 8.50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peridinin Related Antibodies
Molecular Weight

630.81

Formula

C39H50O7
CAS No.
SMILES

CC(C)(C[C@@H](C[C@]1(O)C)OC(C)=O)C1=[C@]=C/C(C)=C/C=C/C=C/C=C(C)/C=C(OC2=O)/C=C2/C=C/[C@]34[C@](O3)(C[C@H](CC4(C)C)O)C
Structure Classification
Initial Source

from Formosan Zoanthid Palythoa mutuki
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Peridinin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peridinin33281-81-1Dengue VirusDENVcis isomersProrocentrum micansDENV-3DENV NS2B/NS3 proteaseDENV-4Huh-7 cellsdengue virus serotypesDENV-2DENV-1Anemonia sulcataInhibitorinhibitorinhibit

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