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Peridinin

Peridinin is a hydroxylated carotenoid ketone that exhibits inhibitory activity against DENV NS2B/NS3 protease and all dengue virus serotypes (DENV-1, DENV-2, DENV-3, DENV-4). Peridinin inhibits dengue virus production and reduces viral titers. Peridinin is applicable to research related to dengue virus infection.

For research use only. We do not sell to patients.

CAS No.: 33281-81-1
Formula: C₃₉H₅₀O₇
Molecular Weight:630.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Peridinin Chemical Structure

CAS No.: 33281-81-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Peridinin (Compound 9) (72 h) potently inhibits four dengue virus serotypes in Huh-7 cells, with the strongest activity against DENV-2 (EC₅₀ = 4.50 μM), and reduces viral titer by 2 log₁₀ at a concentration of 10 μM. The EC₅₀ values against DENV-1, DENV-3, and DENV-4 are 7.62 μM, 5.84 μM, and 6.51 μM, respectively^[1].
Peridinin (72 h) exhibits low cytotoxicity in Huh-7 cells (CC₅₀ = 132.55 μM), resulting in an exceptionally high selectivity index of >29.5 for its anti-DENV-2 activity^[1].
Peridinin (3 days) inhibits DENV NS3 protease activity in Huh-7 cells, with an EC₅₀ of 8.50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 33281-81-1
Molecular Weight 630.81
Formula C₃₉H₅₀O₇
SMILES

CC(C)(C[C@@H](C[C@]1(O)C)OC(C)=O)C1=[C@]=C/C(C)=C/C=C/C=C/C=C(C)/C=C(OC2=O)/C=C2/C=C/[C@]34[C@](O3)(C[C@H](CC4(C)C)O)C
Structure Classification
- Ketones, Aldehydes, Acids
- Others
Initial Source
- Marine natural products
- Other marine organisms
from Formosan Zoanthid Palythoa mutuki
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee JC, et al. Anti-Dengue Virus Constituents from Formosan Zoanthid Palythoa mutuki. Mar Drugs. 2016;14(8):151. Published 2016 Aug 9. [Content Brief]

[2]. PINCKARD JH, et al. Pigments from a marine red water population of the dinoflagellate Prorocentrum micans. Arch Biochem Biophys. 1953 May;44(1):189-99. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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