2. Neuronal Signaling Anti-infection
  3. TMV Amyloid-β
  4. 7-Deoxy-trans-dihydronarciclasine

7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC50: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and APP levels in the cerebral cortex of Tg2576 mice.

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7-Deoxy-trans-dihydronarciclasine

7-Deoxy-trans-dihydronarciclasine Chemical Structure

CAS No. : 145987-74-2

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7-Deoxy-trans-dihydronarciclasine Related Antibodies

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Description

7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC50: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and APP levels in the cerebral cortex of Tg2576 mice[1][2][3].

Cellular Effect
Cell Line Type Value Description References
BXPC-3 GI50
0.046 μg/mL
Compound: 3a
Cytotoxicity against human sBxPC-3 cells
Cytotoxicity against human sBxPC-3 cells
[PMID: 15730244]
DU-145 GI50
0.025 μg/mL
Compound: 3a
Growth inhibition of human DU145 cells
Growth inhibition of human DU145 cells
[PMID: 16441059]
DU-145 GI50
0.04 μg/mL
Compound: 3a
Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
[PMID: 15730244]
Huh-7 CC50
23 μM
Compound: 3
Cytotoxicity against human Huh7.5 cells treated after 96 hrs by MTT assay
Cytotoxicity against human Huh7.5 cells treated after 96 hrs by MTT assay
[PMID: 23511018]
Huh-7 EC50
0.68 μM
Compound: 3
Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells after 96 hrs by fluorescence microscopic analysis
Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells after 96 hrs by fluorescence microscopic analysis
[PMID: 23511018]
KM-20L2 GI50
0.028 μg/mL
Compound: 3a
Growth inhibition of human KM20L2 cells
Growth inhibition of human KM20L2 cells
[PMID: 16441059]
KM-20L2 GI50
0.051 μg/mL
Compound: 3a
Cytotoxicity against human KM20L2 cells
Cytotoxicity against human KM20L2 cells
[PMID: 15730244]
MCF7 GI50
0.034 μg/mL
Compound: 3a
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 15730244]
MCF7 GI50
0.03 μg/mL
Compound: 3a
Growth inhibition of human MCF7 cells
Growth inhibition of human MCF7 cells
[PMID: 16441059]
NCI-H460 GI50
0.037 μg/mL
Compound: 3a
Growth inhibition of human NCI-H460 cells
Growth inhibition of human NCI-H460 cells
[PMID: 16441059]
NCI-H460 GI50
0.043 μg/mL
Compound: 3a
Cytotoxicity against human NCI-H460 cells
Cytotoxicity against human NCI-H460 cells
[PMID: 15730244]
P388 ED50
0.029 μg/mL
Compound: 3a
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
[PMID: 15730244]
P388 ED50
0.02 μg/mL
Compound: 2
Growth inhibition of mouse P388 cells
Growth inhibition of mouse P388 cells
[PMID: 8277308]
P388 ED50
< 0.01 μg/mL
Compound: 3a
Growth inhibition of mouse P388 cells
Growth inhibition of mouse P388 cells
[PMID: 16441059]
SF-268 GI50
0.059 μg/mL
Compound: 3a
Cytotoxicity against human SF-268 cells
Cytotoxicity against human SF-268 cells
[PMID: 15730244]
Vero EC50
0.1 μM
Compound: 7
Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis
Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis
[PMID: 26819664]
Vero IC50
0.037 μg/mL
Compound: 15b
Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
[PMID: 1336040]
Vero IC50
0.039 μg/mL
Compound: 15b
Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
[PMID: 1336040]
Vero IC50
0.057 μg/mL
Compound: 15b
Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
[PMID: 1336040]
Vero IC50
0.25 μg/mL
Compound: 15b
Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay
Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay
[PMID: 1336040]
Vero IC50
0.5 μg/mL
Compound: 15b
Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay
Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay
[PMID: 1336040]
Molecular Weight

293.27

Formula

C14H15NO6
CAS No.
SMILES

O=C1C2=CC(OCO3)=C3C=C2[C@]4([H])[C@@]([C@@H]([C@@H]([C@H](C4)O)O)O)([H])N1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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7-Deoxy-trans-dihydronarciclasine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Deoxy-trans-dihydronarciclasine145987-74-2TMVAmyloid-βTobacco mosaic virusβ-amyloid peptideAβAbetaanti-neuroinflammatorytobacco mosaic virusAPPInhibitorinhibitorinhibit

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Cat. No.:
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