7-Deoxy-trans-dihydronarciclasine

Cat. No.: HY-N12249: Ficha de datos Instrucciones de manejo
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7-Deoxy-trans-dihydronarciclasine, an alkaloid, is a tobacco mosaic virus (TMV) inhibitor (IC₅₀: 1.80 μM). 7-Deoxy-trans-dihydronarciclasine is an anti-neuroinflammatory agent. 7-Deoxy-trans-dihydronarciclasine decreases the Aβ and APP levels in the cerebral cortex of Tg2576 mice.

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7-Deoxy-trans-dihydronarciclasine Estructura química

No. CAS : 145987-74-2

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	0.046 μg/mL Compound: 3a	Cytotoxicity against human sBxPC-3 cells Cytotoxicity against human sBxPC-3 cells	[PMID: 15730244]
DU-145	GI₅₀	0.025 μg/mL Compound: 3a	Growth inhibition of human DU145 cells Growth inhibition of human DU145 cells	[PMID: 16441059]
DU-145	GI₅₀	0.04 μg/mL Compound: 3a	Cytotoxicity against human DU145 cells Cytotoxicity against human DU145 cells	[PMID: 15730244]
Huh-7	CC₅₀	23 μM Compound: 3	Cytotoxicity against human Huh7.5 cells treated after 96 hrs by MTT assay Cytotoxicity against human Huh7.5 cells treated after 96 hrs by MTT assay	[PMID: 23511018]
Huh-7	EC₅₀	0.68 μM Compound: 3	Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells after 96 hrs by fluorescence microscopic analysis Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells after 96 hrs by fluorescence microscopic analysis	[PMID: 23511018]
KM-20L2	GI₅₀	0.028 μg/mL Compound: 3a	Growth inhibition of human KM20L2 cells Growth inhibition of human KM20L2 cells	[PMID: 16441059]
KM-20L2	GI₅₀	0.051 μg/mL Compound: 3a	Cytotoxicity against human KM20L2 cells Cytotoxicity against human KM20L2 cells	[PMID: 15730244]
MCF7	GI₅₀	0.03 μg/mL Compound: 3a	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 16441059]
MCF7	GI₅₀	0.034 μg/mL Compound: 3a	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15730244]
NCI-H460	GI₅₀	0.037 μg/mL Compound: 3a	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 16441059]
NCI-H460	GI₅₀	0.043 μg/mL Compound: 3a	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 15730244]
P388	ED₅₀	<0.01 μg/mL Compound: 3a	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 16441059]
P388	ED₅₀	0.02 μg/mL Compound: 2	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 8277308]
P388	ED₅₀	0.029 μg/mL Compound: 3a	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 15730244]
SF-268	GI₅₀	0.059 μg/mL Compound: 3a	Cytotoxicity against human SF-268 cells Cytotoxicity against human SF-268 cells	[PMID: 15730244]
Vero	EC₅₀	0.1 μM Compound: 7	Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis	[PMID: 26819664]
Vero	IC₅₀	0.037 μg/mL Compound: 15b	Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.039 μg/mL Compound: 15b	Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.057 μg/mL Compound: 15b	Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 1336040]
Vero	IC₅₀	0.25 μg/mL Compound: 15b	Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]
Vero	IC₅₀	0.5 μg/mL Compound: 15b	Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay	[PMID: 1336040]

Peso molecular

293.27

Fòrmula

C₁₄H₁₅NO₆

No. CAS

145987-74-2

SMILES

O=C1C2=CC(OCO3)=C3C=C2[C@]4([H])[C@@]([C@@H]([C@@H]([C@H](C4)O)O)O)([H])N1

Structure Classification

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang YH, et al. Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase. J Nat Prod. 2007 Sep;70(9):1458-61. [Content Brief]

[2]. Zhao D, et al. 7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models. J Agric Food Chem. 2019 Sep 4;67(35):9796-9804. [Content Brief]