Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase

  • J Nat Prod. 2007 Sep;70(9):1458-61. doi: 10.1021/np0702077.
Yue-Hu Wang  1 ,  Zhong-Kai Zhang ,  Fu-Mei Yang ,  Qian-Yun Sun ,  Hong-Ping He ,  Ying-Tong Di ,  Shu-Zhen Mu ,  Yang Lu ,  Ying Chang ,  Qi-Tai Zheng ,  Ming Ding ,  Jia-Hong Dong ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
PMID: 17822295 DOI: 10.1021/np0702077
Abstract

Five new benzylphenethylamine Alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasine, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the new Alkaloids were established by means of extensive spectroscopic methods, and the relative configuration of 1 was further confirmed by single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC(50) = 1.80 microM), a known alkaloid, showed strong activity against tobacco mosaic virus by the half-leaf method. Some of these Alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase. 8-Demethoxy-10-O-methylhostasine was found to possess significant activity, with an IC(50) of 2.32 microM.

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