Infection

Echinosporin (XK-213) is an antibiotic. Echinosporin can be isolated from Amycolatopsis strain. Echinosporin has antifungal activity and antitumor activity.

Biotin-PEG7-C2-S-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses.

Antistaphylococcal agent 1 is an antistaphylococcal therapeutic agent.

HCV NS4A Protein (18-40) (JT strain) is an HCV NS4A peptide, which comprised residues 18 to 40 of the NS4A protein and is known to increase the catalytic efficiency of NS3 protease.

ISIS 1082 sodium scrambled negative control is the sequence scrambled negative control of ISIS 1082 sodium.

VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC₅₀ values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively.

Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces Gö66. Isatropolone A shows potent activity against Leishmania donovani with an IC₅₀ of 0.5 μM.

Herbimycin C is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells (IC₅₀s=7.3 and 1.2 μg/mL, respectively).

Kadsulignan N, a natural product has anti-HIV activity (EC₅₀: 43.56 μM). Kadsulignan N is also a COX-2 ligand (K_i: 72.24 nM).

Cyclo(Pro-dArg) acetate is a chitinase inhibitor. Cyclo(Pro-dArg) acetate inhibits the cell separation of Saccharomyces cerevisiae but does not affect its growth. Cyclo(Pro-dArg) acetate inhibits the transition of Candida albicans from yeast to filamentous morphology.

PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC₅₀: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria.

Clerocidin dimer is a dimeric clerodane derivative antibiotic that can be found in fermentations of the fungus Oidiodendron truncatum. Clerocidin dimer exhibits antibiotic activity.

NA-CATH is an antibacterial peptide with effective antibacterial activity against Francisella novicida (EC₅₀ = 1.54 µg/mL). NA-CATH does not cause significant hemolysis at a concentration of 100 µg/mL. NA-CATH is commonly used in the study of bacterial infections.

Kanzonol Y is a chalcone compound that can be found in the roots of Glycyrrhiza glabra. Kanzonol Y exerts anticancer and anti-dengue virus activity.

ACHE-IN-38 (hydrochloride) (Standard) is the analytical standard of ACHE-IN-38 (hydrochloride). This product is intended for research and analytical applications. ACHE-IN-38 hydrochloride (Compound 13b) inhibits the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviates memory deficits in patients with Alzheimer’s Disease by potentiating cholinergic transmission.

HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. HDAC1-IN-3 shows antimalarial activity in wild-type and multidrug-resistant parasite strains. HDAC1-IN-3 shows a significant in vivo killing effect against all life cycles of parasites.

Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC₅₀ values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A.

CPZEN-45 is a bacterial translocase I inhibitor with potent anti-tuberculosis activity. CPZEN-45 is promising for research of tuberculosis.

Apigenin-4'-α-L-rhamnoside is a potent inhibitor of HBV. Apigenin-4'-α-L-rhamnoside inhibits the secretory level of HBV surface antigen (HBsAg) in HepG2.2.15 cells.

HL-3-47 is an inhibitor binding to subsites S1 and S2 in SARS-CoV-2 main protease.