A 33903

Cat. No.: HY-108002: Data Sheet Handling Instructions
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A 33903 is a respiratory syncytial virus (RSV) replication inhibitor. A 33903 can be used for the research of RSV-infection.

For research use only. We do not sell to patients.

A 33903 Chemical Structure

CAS No. : 70890-53-8

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Description

A 33903 is a respiratory syncytial virus (RSV) replication inhibitor. A 33903 can be used for the research of RSV-infection^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	CC₅₀	> 50 μM Compound: A-33903	Cytotoxicity against RSV RSS infected human Hep2 cells after 6 days by XTT assay Cytotoxicity against RSV RSS infected human Hep2 cells after 6 days by XTT assay	[PMID: 17576833]
HEp-2	EC₅₀	10.1 μM Compound: A-33903	Antiviral activity against RSV RSS infected human Hep2 cells assessed as reduction of viral antigen synthesis after 3 days by ELISA Antiviral activity against RSV RSS infected human Hep2 cells assessed as reduction of viral antigen synthesis after 3 days by ELISA	[PMID: 17576833]
HEp-2	EC₅₀	15.1 μM Compound: A-33903	Antiviral activity against RSV A2 infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV A2 infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	27.6 μM Compound: A-33903	Antiviral activity against plaque picked A-33903-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay Antiviral activity against plaque picked A-33903-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	3.5 μM Compound: A-33903	Antiviral activity against RSV B infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV B infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	7.2 μM Compound: A-33903	Antiviral activity against RSV Long infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV Long infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	8.1 μM Compound: A-33903	Antiviral activity against DMSO-passaged wild type RSV RSS infected human Hep2 cells by plaque reduction assay Antiviral activity against DMSO-passaged wild type RSV RSS infected human Hep2 cells by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	9.6 μM Compound: A-33903	Antiviral activity against RSV RSS infected human Hep2 cells assessed as inhibition of virus-induced cell death after 6 days by XTT assay Antiviral activity against RSV RSS infected human Hep2 cells assessed as inhibition of virus-induced cell death after 6 days by XTT assay	[PMID: 17576833]
HEp-2	EC₅₀	9.7 μM Compound: A-33903	Antiviral activity against RSV RSS infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV RSS infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	> 100 μM Compound: A-33903	Antiviral activity against plaque picked RSV604-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay Antiviral activity against plaque picked RSV604-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay	[PMID: 17576833]
HEp-2	IC₅₀	17.6 μM Compound: 18	Antiviral activity against RSV Long in Hep2 cells by ELISA Antiviral activity against RSV Long in Hep2 cells by ELISA	[PMID: 16570927]
HEp-2	IC₅₀	17.8 μM Compound: 18	Antiviral activity against RSV B in Hep2 cells by ELISA Antiviral activity against RSV B in Hep2 cells by ELISA	[PMID: 16570927]
HEp-2	IC₅₀	3.6 μM Compound: 18	Antiviral activity against RSV B in Hep2 cells by plaque assay Antiviral activity against RSV B in Hep2 cells by plaque assay	[PMID: 16570927]
HEp-2	IC₅₀	7.1 μM Compound: 18	Antiviral activity against RSV RSS in Hep2 cells by plaque assay Antiviral activity against RSV RSS in Hep2 cells by plaque assay	[PMID: 16570927]
HEp-2	IC₅₀	7.2 μM Compound: 18	Antiviral activity against RSV Long in Hep2 cells by plaque assay Antiviral activity against RSV Long in Hep2 cells by plaque assay	[PMID: 16570927]
HEp-2	IC₅₀	8.6 μM Compound: 18	Antiviral activity against RSV RSS in Hep2 cells by whole cell XTT assay Antiviral activity against RSV RSS in Hep2 cells by whole cell XTT assay	[PMID: 16570927]
HEp-2	IC₅₀	9.3 μM Compound: 18	Antiviral activity against RSV RSS in Hep2 cells by ELISA Antiviral activity against RSV RSS in Hep2 cells by ELISA	[PMID: 16570927]
Sf9	IC₅₀	> 10 μM Compound: figure 3, R4C2	Displacement of [3H]Ro15-4513 from GABAA alpha-1-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system Displacement of [3H]Ro15-4513 from GABAA alpha-1-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system	[PMID: 18537233]
Sf9	IC₅₀	> 10 μM Compound: figure 3, R4C2	Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system	[PMID: 18537233]

Molecular Weight

293.32

Formula

C₁₇H₁₅N₃O₂

CAS No.

70890-53-8

SMILES

O=C(C)NC1N=C(C2=C(NC1=O)C=CC=C2)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chapman J, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication[J]. Antimicrobial agents and chemotherapy, 2007, 51(9): 3346-3353. [Content Brief]

A 33903 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A 3390370890-53-8A33903A-33903RSVRespiratory syncytial virusrespiratory syncytial virusinfectionInhibitorinhibitorinhibit

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A 33903

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